朱健康和邓兴旺_邓兴旺 北京大学_邓兴旺博士简介

  本文关键词：邓兴旺，由笔耕文化传播整理发布。

邓兴旺 博士，资深研究员，所长 Xing Wang Deng, Ph.D., Investigator, The Director of National Institute of Biological Sciences, Beijing.
电话（Tel）：010-80726688-8388
传真（Fax）：010-80726689
E-mail：dengxingwang@nibs.ac.cn

教育经历Education
1982年 北京大学生物系植物生理生化专业学士
B.S, Plant Biochemistry and Physiology, Department of Biology, 1978-1982,
Beijing University, Beijing, China.
1989年 加利福尼亚大学伯克利分校植物生理及分子生物学博士
Ph.D, Molecular and Physiological Plant Biology, 1985-1989,
University of California at Berkeley, USA
工作经历Professional Experience
2003年任北京生命科学研究所所长
The Director of National Institute of Biological Sciences, Beijing
2003-present Named Daniel C. Eaton Professor of Plant Biology at Yale（耶鲁大学植物生物学冠名教授）
2001-present Professor, Department of MCD Biology, Yale University（耶鲁大学分子与细胞发育生物学系教授）
2000-present Director, the Peking-Yale joint center for Plant Molecular Genetics and Agribiotechnology（北大-耶鲁植物分子遗传学及农业生物技术联合中心主任）
1998-2001 Associate Professor with tenure, Department of MCD Biology, Yale University（耶鲁大学分子与细胞发育生物学系终身职副教授）
1995-1998 Associate Professor with term, Department of MCD Biology, Yale University（耶鲁大学分子与细胞发育生物学系副教授）
1992-1995 Assistant professor, Department of Biology, Yale University（耶鲁大学分子与细胞发育生物学助理教授）
1989-1991 Post-doctoral research---Molecular and genetic analysis of photomorphogenesis in Arabidopsis thaliana, and in vitro Dnase I footprinting analysis of nuclear protein-promoter interactions of Oat PhyA gene. （博士后研究—拟南芥光形态建成的分

子生物学和遗传学分析，及燕麦PhyA基因核蛋白—启动子相互作用的体外Dnase I指纹分析）
1986-1989 Ph.D graduate research on regulation of plastid gene expression in higher plant. （博士学位研究—高等植物质体基因的表达）
1985-1986 Graduate research on higher plant thylakoid membrane protein phosphorylation and its relation to the regulation of light energy absorption in two photosystems. （研究生新生研究—高等植物类囊体膜蛋白磷酸化及其与两个光合系统中光能吸收的关系）
1982-1985 Master degree graduate research on the regulation of light energy distribution between two photosystems in higher plants. （硕士学位研究—高等植物两个光合系统中光能分布的调节）
1981-1982 Undergraduate research on biochemical characterization of a nuclear encoded male sterile mutant of wheat. （学士学位研究—一个细胞核编码的小麦雄性不育突变体的生化特征）
SOCIETY:
Member of the American society of plant physiologists
Member of the American Society for the Advancement of Science
EXTRAMURAL SERVICES
Scientific Advisory Board Member for MPI for Plant Breeding Research (2003-2008)
Scientific Review Group Member for Sansbury Laboratory (2003)
Associate Editor for “Genes to Cell” journal
Associate editor for “Photochemistry and Photobiology” journal（1997-2003）
Associate editor for “Plant Molecular Biology” journal
Advisory board member of “Signal Transduction”
Advisory board member of “Plant journal”(1996-2003)
Adhoc Member for two NIH study sections
Co-session Chair for Plant Development in 18th International Congress of Genetics, August 10-5, 1998, Beijing, China.
Co-organizer of CSHL Summer Course "Arabidopsis Molecular Genetics", 1995-1997 and 1999
Photomorphogenesis session chair in "Signaling in Plant Development", a CSHL meeting bewteen. Sept. 27-Oct. 1, 1995. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Environmental Response session chair in 7th International Conference on Arabidopsis Research, Norwich, UK. 23-27 June, 1996
NOTABLE HONORS 
2
2003: The Kumho Science International Award-2003 by The International Society for Plant Molecular Biology (ISPMB)
1995: Presidential Faculty Fellow Award
1989: Post-doctoral Fellowship of Life Sciences Research Foundation.
研究概述：Research Description
我们的研究兴趣主要在细胞外刺激引起的细胞信号传递过程及其对机体发育的调节。主要集中在两方面：光调控的拟南芥幼苗的发育过程以及其在哺乳动物中普遍保守的一种细胞信号传递途径。我们在研究光信号对拟南芥发育调节的信号通路时，找到了10个多效性COP/DET/FUS位点，确定它们介导了光对拟南芥幼苗发育过程的调节。其中，COP1是拟南芥光形态建成的关键的抑制因子，在暗中在细胞核内作为E3通过26S蛋白体降解促进光形态建成的转录因子，而在光下COP1活性被抑制且在核内的丰度降低；另外一个基因COP10编码一个类似E2的蛋白，并以多亚基蛋白复合体存在。其余的多数基因编码一个高度保守的多亚基蛋白COP9复合体（COP9 signalosome）的不同亚基，COP9复合体是一个新的E3连接酶的调节因子，可以促进NEDD8/RUB1从特定的E3连接酶上解离下来。COP9复合体是细胞对外界刺激或胁迫产生反应的新的调节成分。目前，我们正在采用分子遗传和基因组学的方法，进一步深入地研究我们发现的在所有多细胞有机体中都保守的细胞调节蛋白及复合体的功能。我们希望了解胞外信号调节这些蛋白及复合体的信号转导机制，，以及在环境刺激发生反应时这些蛋白及复合体对基因组表达模式的调节。
We are interested in the cellular signaling process responsible for regulation of development by extracellular stimuli. We used two model systems: the light control of Arabidopsis seedling development and a conserved cellular pathway in mammals. During our dissection of the genetic network involved in light control of Arabidopsis development, ten pleiotropic COP/DET/FUS loci have been identified and revealed to be responsible for mediating light control of Arabidopsis seedling developmental program switch. Among them, COP1 is the master repressor of photomorphogenic development and acts within the nucleus as an E3 ligase by directly targeting photomorphogenesis-promoting transcription factors’ degradation by the 26S proteasome in darkness. Light inactivates COP1 and causes a reduction in its nuclear abundance. Another gene, COP10, encodes a likely E2 component. Most remaining genes encode subunits of a highly conserved multi-subunit protein complex, the COP9 signalosome, which defines a novel regulator of the E3 ligases and promotes de-conjugation of NEDD8/RUB1 from certain E3 ligases. Therefore this group of regulators define new cellular machineries in regulating cellular responses to external stimuli or stresses. Currently, we are applying both molecular genetics and genomic approaches to further analyze this group of novel cellular machineries conserved among all multicellular organisms. We wish to understand signaling mechanisms in how extracellular signals regulate those machineries and how the machineries control the genome expression pattern in response to the environmental signals.

发表文章： Publications
(See for citation summary)
1. Wei, N., and Deng, X. W. (2003). The COP9 signalosome. Ann. Rev. Cell. Dev. Biol. 19. 261-286
2. Yusuke Saijo, James A. Sullivan, Haiyang Wang, Jianping Yang, Yunping Shen, Vicente Rubio, Ligeng Ma, Ute Hoecker, and Xing Wang Deng (2003). The COP1-SPA1 interaction defines a critical step in Phytochrome A-mediated regulation of HY5 activity. Genes & Dev. Nov 1;17(21): 2642-2647
3. Yuling Jiao, Hongjuan Yang, Ligeng Ma, Ning Sun, Haiyuan Yu, Tie Liu, Ying Gao, Hongya Gu, Zhangliang Chen, Masamitsu Wada, Mark Gerstein, Hongyu Zhao, Li-Jia Qu*, and Xing Wang Deng (2003). A genome wide analysis of blue light regulation of Arabidopsis transcription factor gene expression during seedling development. Plant Physiol. Dec; 133(4): 1480-1493
4. Lei, L., and Deng, X.W. (2003). The COP9 signalosome: an alternative lid for the 26S proteasome? Trend in Cell Biol. Oct; 13(10): 507-509
5. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N (2003). Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol. Cell. Biol. 23(19), 6790-6797.
6. Sullivan, J. A. And Deng, X. W. (2003). From seed to seed: the role of photoreceptors in Arabidopsis development. Developmental Biology 260, 289-297.
7. Zhaohua Peng, Yunping Shen, Suhua Feng, Xiping Wang, Brahma Nanda Chitteti, Richard D. Vierstra, and Xing Wang Deng (2003). Evidence for a physical association of the COP9 signalosome, the proteasome, and specific SCF E3 ligases in vivo. Current Biology13, R504-5.
8. Ping Wu, Ligeng Ma, Xingliang Hou, Mingyi Wang, Yungrong Wu, Feiyan Liu, and Xing Wang Deng (2003). Phosphate Starvation Triggers Distinct Alterations of Genome Expression in Arabidopsis Roots and Leaves. Plant Physiology 132,1260-71.
9. Serino, G., and Deng, X. W. (2003). The COP9 signalosome: regulating plant development through the control of proteolysis. Ann. Rev. Plant. Mol. Biol. 54, 165-82.
10. Wang, H. Y., and Deng, X. W. (2003). Dissecting the Phytochrome A dependent signaling network in higher plants. Trends In Plant Sciences 8,172-178.
11. Xiping Wang, Suhua Feng, Naomi Nakayama, W. L. Crosby, Vivian Irish, Xing-Wang Deng, Ning Wei (2003). The COP9 Signalosome Interacts with SCFUFO and Participates in Arabidopsis Flower Development. Plant Cell 15, 1071-82.
12. Feng, S., Ma, L., Wang, X., Xie, D., Dinesh-Kumar, S. P., Wei, N., and Deng, X. W. (2003). The COP9 Signalosome Physically Interacts with SCFCOI1 and Modulates Jasmonate Responses. Plant Cell 15,1083-1094.
13. Serino, G., Su, H. W., Peng, Z. H., Tsuge, T., Wei, N., Gu, H. Y., and Deng, X. W. (2003). Characterization of the last subunit of Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15: 719-731.
14. Ma, L. G., Zhao, H. Y.,and Deng, X. W. (2003). Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development 130, 969-981.
15. Chunling Yi , Haiyang Wang , Ning Wei and Xing Wang Deng (2002). An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biology, 3(1):30. ().
16. Wang H, Ma L.G, Habashi, J., Li J.M, Zhao H.Y, Deng X.W. (2002). Analysis of far-red light regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis. Plant J. 32: 723-733.
17. Ligeng Ma, Ying Gao, Lijia Qu, Zhangliang Chen, Jinming Li, Hongyu Zhao, and Xing Wang Deng (2002). Genomic evidence for COP1 as repressor of light regulated gene expression and development in Arabidopsis. Plant Cell 14, 2383-2398.
18. Claus Schwechheimer, Giovanna Serino, and Xing Wang Deng (2002). The COP9 signalosome and AXR1 are required for multiple E3 ubiquitin ligase-mediated processes in Arabidopsis thaliana. Plant Cell 14, 2553-2563.
19. Yadav V, Kundu S, Chattopadhyay D, Negi P, Wei N, Deng XW, Chattopadhyay S.(2002). Light regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory , COP1 and HY5, in Arabidopsis. Plant J. 31(6), 741-753.
20. Rebecca C. Fry, Jessica Habashi, Haruko Okamoto and Xing-Wang Deng (2002). Characterization of a Dominant phyA Mutation Reveals a Distinction of Phytochrome A and Phytochrome B Signal Propagation . Plant Physiology 130, 457-465.
21. Yule Liu, Michael Schiff, Giovanna Serino, Xing-Wang Deng, and Savithramma P. Dinesh-Kumar (2002). Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to tobacco mosaic virus. Plant Cell 14:1483-1496..
22. Magnus Holm, Li-Geng Ma, Li-Jia Qu and Xing-Wang Deng (2002). Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Gene&Dev. 16:1247-1259.
23. Christian S. Hardtke, Haruko Okamoto, Chatanika Stoop-Myer and Xing-Wang Deng (2002). Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Plant J. 30, 385-394.
24. Claus Schwechheimer and Xing-Wang Deng (2002). FPLC Gel Filtration pp. 226-228, In Weigel, D., and Glazebrook, J. ed. “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Jessica Habashi and Xing-Wang Deng (2002). Nondenaturing Gel Electrophoresis of Proteins. pp. 228-233, In Weigel, D., and Glazebrook, J. ed “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
26. Giovanno Serino and Xing Wang Deng (2002). Protein Coimmunoprecipitation. pp. 233-237. In Weigel, D., and Glazebrook, J. ed “Arabidopsis-A Laboratory Manual”. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
27. Genki Suzuki, Yuki Yanagawa, Shing F. Kwok, Minami Matsui, and Xing-Wang Deng (2002). Arabidopsis COP10 is an ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Gene&Dev. 16, 554-559 .
28. Haiyang Wang and Xing Wang Deng (2002). Arabidopsis FHY3 defines a key phytochrome A signaling component directly interacting with its homologous partner FAR1. EMBO J. 21(6):1339-1349.
29. Haiyang Wang and Xing Wang Deng (2002). Phytochrome signaling. In The Arabidopsis Book, eds. C.R. Somerville and E.M. Meyerowitz, American Society of Plant Biologists, Rockville, MD, DOI 10.1199-tab.0074 ()
30. Schwechheimer, C., and Deng, X. W. (2002). Studying protein-protein interactions with the yeast two-hybid system. Chapter 9 in “Molecular Plant Biology: A practical Approach”, volume II, pages 173-198.
31. Ligeng Ma, Jinming Li, Lijia Qu, Zhangliang Chen, Hongyu Zhao, and Xing Wang Deng (2001). Light control of Arabidopsis development entails co-ordinated regulation of genome expression and cellular pathways. Plant Cell 13, 2589-2607.
32. Zhaohua Peng, Giovanna Serino, and Xing-Wang Deng (2001). Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted development processes in Arabidopsis. Plant Cell 13, 2393-2407.
33. Zhaohua Peng, Giovanna Serino, and Xing-Wang Deng (2001). A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3. Development 128, 4277-4288.
34. Wang H, Ma L.G, Li J.M, Zhao H.Y, Deng X.W. (2001). Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294, 154-158. (epublication and news on16th August).
35. Haruko Okamoto, Lijia Qu, Xing Wang Deng (2001). EID1, aids the fine-tuning of phytochrome A signal transduction in Arabidopsis? Plant Cell 13:1983-1986.
36. Schwechheimer, C., and Deng, X. W. (2001). The COP9 signalosome revisited: A novel mediator of protein degradation. Trends Cell Biol. 11, 420-426.
37. Haruko Okamoto, Minami Matsui, Xing Wang Deng (2001) Overexpression of the heterotrimeric G-protein 　-subunit enhances phytochrome mediated inhibition of hypocotyl elongation in Arabidopsis. Plant Cell 13, 1639-1652.
38. Schwechheimer, C., G. Serino , Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R. J., Gray, W. M., Estelle, M., and Deng, X. W. (2001). The COP9 signalosome associates with SCFTIR1 ubiquitin ligase and plays a critical role for SCFTIR1-mediated auxin responses. SCIENCE, 292 (May 18), 1379-1382 (news focus on May 3 issue).
39. Zhaohua Peng, Jeffrey M. Staub, Giovanna Serino, Shing F. Kwok , Jasmina Kurepa, Barry D. Bruce, Richard D. Vierstra, Ning Wei, and Xing-Wang Deng (2001). The cellular level of PR500, a protein complex related to the 19S regulatory particle of the proteasome, is regulated in response to stresses in plants. Mol. Biol. Cell 12, 383-392.
40. Magnus Holm, Christian S. Hardtke, Rachelle Gaudet, and Xing-Wang Deng (2001). Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. 20: 118-127.
41. Yoshiharu Y. Yamamoto, Xing-Wang Deng, and Minami Matsui (2001). CIP4, a new COP1 target, is a nuclear-localized positive regulator of Arabidopsis photomorphogenesis. Plant Cell 13, 399-411.
42. Jiang CJ, Shoji K, Matsuki R, Baba A, Inagaki N, Ban H, Iwasaki T, Imamoto N, Yoneda Y, Deng XW, Yamamoto N (2001). Molecular cloning of a novel importin a homologue from rice, by which COP1 NLS-protein is preferentially nuclear imported. J Biol Chem. 276(12):9322-9329.
43. Abel S, Blazquez M, Dangl J, Deng XW, Graham I, Harada J, Jones J, Nilsson O. (2000). Arabidopsis Research 2000. Plant Cell. 12, 2302-2308.
44. CS. Hardtke, and XW Deng (2000). The cell biology of the COP/DET/FUS proteins: regulating proteolysis in photomorphogenesis and beyond? Plant Physiol. 124: 1548-1557.
45. Osterlund, M. T., Wei, N., and X.W. Deng (2000). The Roles of Photoreceptor Systems and the COP1-Targeted Destabilization of HY5 in Light Control of Arabidopsis Seedling Development. Plant Physiol. 124: 1520-1524.
46. Schwechheimer, C., and Deng, X. W. (2000). The COP/DET/FUS proteins---regulators of eukaryotic growth and development. Sem. Cell Dev. Biol. 11, 495-503.
47. CS. Hardtke, K. Gohda, MT. Osterlund, T. Oyama, K. Okada, and XW Deng (2000). HY5 stability and activity in Arabidopsis is regulated by phosphorylationin its COP1 binding domain. EMBO J. 19, 4997-5006.
48. O. Leyser and Deng, XW (2000). Cell signaling and gene regulation: new directions in plant signalling. Curr. Opin. Plant Biol. 3, 351-352.
49. Dingming Kang, Xiping Wang, Kaiming Cao, Chongrong Sun, Xing-Wang Deng, and Ning Wei. (2000). Functional conservation of COP9 signalosome among diverse organisms revealed by expressing heterologous subunit genes in Arabidopsis. Plant Journal, 23, 597-608.
50. Hsu-Liang Hsieh, Haruko Okamoto, Mingli Wang, Lay-Hong Ang, Minami Matsui, Horward Goodman, and Xing Wang Deng (2000). FIN219, an auxin-regulated gene, defines a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development. Genes Dev. 14: 1958-1970.
51. Deng, X.W., Dubiel, W., Wei, N., Hofmann, K., Mundt, K., Colicelli, J., Kato, J.Y., Naumann, M., Segal, D., Seeger, M., Glickman, M., Carr, A., and Chamovitz, D. A. (2000). Unified nomenclature for the COP9 signalosome: an essential regulator of development. Trends Genetics. 16, 202-203.
52. Osterlund, M. T., Hardtke, C., Wei, N., and X.W. Deng (2000). Targeted destabilization of HY5 during light regulated development of Arabidopsis. Nature 405, 462-466.
53. Yamamoto, Y. Y., Puente, P., and X. W. Deng (2000). Cotyledon-specific albino mutants of Arabidopsis defective in chloroplast gene expression and 16S rRNA maturation. Plant Cell and Physiology 41, 68-76.
54. Stoop-Myer, C., Torii, K., U., McNellis, T. W., Coleman, J., and Deng, X. W. (1999). The N-terminal fragment of Arabidopsis photomorphogenic repressor COP1 maintains partial function and acts in a concentration dependent manner. Plant J. 20, 713-717.
55. Holm, M., and Deng, X. W. (1999). Structural organization and interactions of COP1, a light regulated developmental switch. Plant Mol. Biol 41, 151-158.
56. Yamamoto, N., and X. W. Deng (1999). Protein nucleocytoplasmic transport and its light regulation in plants. Genes to Cell 4(9):489-500.
57. Torii, K. U., Stoop-Myer, C. D., Okamoto, H., Coleman, J. E., Matsui, M., and Deng, X. W. (1999). The RING-finger Motif of Photomorphogenic Repressor COP1 specifically interacts with the RING-H2 Motif of a novel Arabidopsis protein. J. Biol. Chem. 274, 27674-27681.
58. Serino, G., Tsuge, T., Kwok, S.F., Matsui, M., Wei, W., and Deng, X.W. (1999). Arabidopsis cop8 and fus4 mutations define the same locus that encodes subunit 4 of the COP9 signalosome. Plant Cell 11, 1967-1979 .
59. Deng, X. W., and Quail, P. H. (1999). Signaling in light-controlled development. Sem. Cell Dev. Biol. 10, 121-129.
60. Haiyang Wang, Dingming Kang, Xing Wang Deng, and Ning Wei (1999). Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. Curr. Biol. 9, 711-714.
61. Wei, N., and X. W. Deng (1999). Making sense of the COP9 signalosome, a conserved regulatory protein complex from Arabidopsis to human. Trends Genet. 15, 98-103.
62. Osterlund, M. T., Ang, L. H., and X.W. Deng (1999). The molecular and cellular basis of COP1 as a repressor of photomorphogenic development in Arabidopsis . Trends in Cell Biol. 9, 113-118.
63. Kwok SF, Staub JM, Deng X-W (1999): Characterization of Two Subunits of Arabidopsis 19S Proteasome Regulatory Complex and its Possible Interaction with the COP9 complex. J. Mol. Biol. 285, 85-95.
64. Yamamoto, Y. Y., and X. W. Deng (1998). A New Vector Set for GAL4-Dependent Transactivation Assay in Plants. Plant Biotechnology 15, 217-220.
65. Karniol, B., Yahalom, A., Kwok, S. F., Tsuge, T., Matsui, M., Deng, X.-W., and Chamovitz, D. A. (1998). The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS lett. 439, 173-179.
66. von Arnim, A. G., Deng, X. W., and Stacey, M. G. (1998). Cloning vectors for the expression of green fluorescent protein fusion proteins in transgenic plants. Gene 221, 35-43.
67. Kwok SF, Tsuge T, Solano R, Chamovitz DA, Matsui M, Ecker JR, Deng X-W (1998). Arabidopsis Homologs of a c-Jun Coactivator Are Present both in monomeric form and in the COP9 Complex and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell 10, 1779-1790.
68. Mark T. Osterlund, and Xing-Wang Deng (1998). Multiple Photoreceptors mediate the light induced reduction of GUS-COP1 from Arabidopsis hypocotyl nuclei. Plant J. 16, 201-208.
69. Torii, K., McNellis, T. W., and X. W. Deng (1998). Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. EMBO J., 17(19):5577-5587.
70. Yamamoto, Y. Y., Matsui, M., and X. W. Deng (1998). Positive feedback in plant signaling pathways. Trends in Plant Science 3, 374-375.
71. Wei, N., and X. W. Deng (1998). Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants. Photochem Photobiol. 68(2): 237-241.
72. Ning Wei, Tomohiko Tsuge, Giovanna Serino, Naoshi Dohmae, Koji Takio, Minami Matsui, and Xing-Wang Deng (1998). The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 8(16): 919-922.
73. Yamamoto, Y. Y., Matsui, M., Ang, L.H., and X. W. Deng (1998) The role of a COP1 interactive protein in mediating light-regulated gene expression in Arabidopsis. Plant Cell 10, 1083-1094.
74. Sudip Chattopadhyay, Pilar Puente, Xing-Wang Deng, and Ning Wei (1998). A critical role of combinatorial interaction of light-responsive elements in determining the response characteristics of light-responsive promoters in Arabidopsis. Plant J. 15, 69-77.
75. Chamovitz, D. A., and Deng, X. W. (1998). Molecular approaches to biochemical purification: the COP9 complex paradigm. NATO ASI series, vol. H104, 83-91.
76. Sudip Chattopadhyay, Lay-Hong Ang, Pilar Puente, Xing-Wang Deng, and Ning Wei (1998). Arabidopsis bZIP protein HY5 acts between COP1 and light-responsive promoters in mediating light control of gene expression. Plant Cell 10, 673-683.
77. Lay-Hong Ang, Sudip Chattopadhyay, Tokitaka Oyama, Kiyotaka Okada, Ning Wei, and Xing Wang Deng (1998). Molecular interaction between COP1 and HY5 defines a developmental switch for light control of Arabidopsis development. Molecular Cell 1, 213-222.
78. Deng, XW (1997). Light control of Arabidopsis development pattern. SEB Symposium 51: Control of Plant Development-Genes and Signals. p.93-96.
79. von Arnim, A. G., Mark T. Osterlund, Shing F. Kwok, and X. W. Deng (1997). Genetic and developmental control of nuclear accumulation of COP1, a repressor of photomorphogenesis in Arabidopsis. Plant Physiol. 114, 779-788.
80. Torii, K. U., and X. W. Deng (1997). The role of COP1 in light control of Arabidopsis seedling development. Plant Cell and Environ. 20, 728-733.
81. Chamovitz, D. A., and X. W. Deng (1997). The COP9 complex: a link between photomorphogenesis and general developmental regulation. Plant Cell and Environ. 20, 734-739.
82. Staub J. M., and X. W. Deng (1996). Light signal transduction in plants. PHOTOCHEM. and PHOTOBIOL. 64(6), 897-905.
83. von Arnim, A. G., and X. W. Deng (1996). A role for transcriptional repression during light control of plant development. BioEssay 18 (11), 905-910.
84. N. Wei, and X. W. Deng (1996). The role of the pleiotropic COP/DET/FUS genes in light control of Arabidopsis seedling development. Plant Physiol. 112, 871-878.
85. Staub J. M., N. Wei, and X. W. Deng (1996). Evidence for COP11 as a component of the nuclear localized COP9 complex in Arabidopsis. PLANT CELL 8, 2047-2056.
86. McNellis T. W., Torii, K., and X. W. Deng (1996). Expression of an N Terminal Fragment of COP1 Confers Dominant-Negative Suppression of Seedling Photomorphogenic Development in Transgenic Arabidopsis. PLANT CELL 8, 1491-1503.
87. Pilar Puente, Ning Wei and Xing Wang Deng (1996). Combinatorial interplay of promoter elements constitutes the minimal determinants for light and developmental control of gene expression in Arabidopsis. EMBO J. 15, 3732-3743.
88. Chamovitz, D. A., N. Wei, M. Osterlund, A. G. von Arnim, J. M. Staub, M. Matsui, and X. W. Deng (1996). The Arabidopsis COP9 complex, a novel multisubunit nuclear regulator involved in light control of a developmental switch. CELL, 86, 115-121.
89. Chamovitz, D. A., and X. W. Deng (1996). Light signaling in plants. Critical Reviews in Plant Sciences 15, 455-478.
90. von Arnim, A. G., and X. W. Deng (1996). Light control of seedling development. Annu. Rev. of Plant Physiol. and Plant Mol. Biol. 47, 215-243.
91. Kwok, S. F., Piekos, B., Misera, S. and X. W. Deng (1996). A complement of ten essential and pleiotropic Arabidopsis COP/DET/FUS genes are necessary for repression of photomorphogenesis in darkness. Plant Physiol. 110, 731-742.
92. Kwok, S. F., and X. W. Deng (1996). The role of the pleiotropic Arabidopsis COP/DET/FUS genes in repression of photomorphogenic development in darkness. In “Current Topics in Plant Physiology: an American Society of Plant Physiologists Series on [regulation of plant growth and development by light]”. vol 17, pg.134-143.
93. Torii, K. U., and X. W. Deng (1995). Regulation of plant form: identification of a molecule controlling cell expansion. BioEssays 17 (5), 383-386
94. McNellis, T. W., and X. W. Deng (1995). Light control of seedling morphogenetic Pattern. Plant Cell 7, 1749-1761.
95. Chamovitz, D. A., and X. W. Deng (1995). The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. Cell 82, 353-354.
96. Matsui, M., Stoop, C. D., von Arnim, A. G., Wei, N., and X. W. Deng (1995). Arabidopsis COP1 specifically interacts in vitro with a novel cytoskeleton associated protein. Proc. Natl. Acad. Aci. USA 92, 4239-4243.
97. von Arnim, A. G., and X. W. Deng (1994). Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleoplasmic partitioning. CELL 79, 1035-1045.
98. McNellis, T. W., von Arnim, A. G., and X. W. Deng (1994). Evidence for Arabidopsis COP1 as an autonomous light-inactivatable repressor of photomorphogenic develoment. PLANT CELL 6, 1391-1400.
99. N. Wei, D. Chamovitz, and X. W. Deng (1994). Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. CELL 78, 117-124.
100. N. Wei, S. F. Kwok, A. G., von Arnim, A. Lee, T. McNellis, B. Piekos, and X. W. Deng (1994). Arabidopsis COP8, COP10, COP11 genes are involved in repression of photomorphogenic development in darkness. Plant Cell 6, 629-643.
101. L. H. Ang and X. W. Deng (1994). Regulatory hierarchy of photomorphogenic loci: allele-specific and light dependent interaction between the COP1 and HY5 loci. Plant Cell 6. 613-628.
102. McNellis, T., von Arnim, A. G., Araki, T., Komeda, Y., Misera, S., and Deng, X.-W. (1994). Genetic and molecular analysis of a allelic series of Arabidopsis cop1 mutants evealed functional roles of its protein domains. Plant Cell 6, 487-500.
103. Deng, X. W. (1994). Fresh view of light signal transduction in plants. Cell 76, 423-426.
104. Albrecht, G. von Arnim, and Xing-Wang Deng (1993). The Ring-finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain. J. Biol. Chem. 268, 19626-19631.
105. Yongmin Hou, Abrecht G. von Arnim, and Xing-Wang Deng (1993). A new class of Arabidopsis constitutive photomorphogenic genes involved in regulating cotyledon development. Plant Cell 5, 329-339.
106. Ning Wei, and Xing-Wang Deng (1992). COP9, a new genetic locus involved in light-regulated development and gene expression in Arabidopsis. Plant Cell 4, 1507-1518.
107. Deng, X.-W. Matsui, M., Wei, N., Wagner, D., Chu, A. M., Feldmann, K. A., and Quail, P. H. (1992). COP1, an Arabidopsis regulatory gene, encodes a protein with both a Zn-binding motif and a Gb-protein homologous domain. Cell, 71, 791-801.
108. Tonkyn, J. C., X. W. Deng, and W. Gruissem (1992). Regulation of plastid gene expression during photooxidative stress. Plant Physiol. 99, 1406-1415.
109. Deng, Xing-Wang and Peter H. Quail (1992). Genetic and phenotypic characterization of cop1 mutants of Arabidopsis thaliana. The Plant Journal, 2:83-95.
110. Deng, Xing-Wang, Timothy Caspar, and Peter H. Quail (1991). cop1: a regulatory locus involved in light-controlled development and gene expressio in Arabidopsis. Genes Dev. 5:1172-1182.
111. Wesley B. Bruce, Deng, Xing-Wang, and Peter H. Quail (1991). A negatively acting DNA sequence element mediate phytochrome-directed repression of phyA gene transcription. EMBO J. 10(10):3015-3024.
112. Deng, Xing-Wang, Rod A. Wing and Wilhelm Gruissem (1989). Chloroplast DNA exists as multimeric forms. Proc. Natl. Acad. Sci. USA 86:4156-4160.
113. Deng, Xing-Wang, John C. Tonkyn, Gary F. Peter, J. Philip Thornber and Wilhelm Gruissem (1989). Post-transcriptional control of plastid mRNA accumulation during adaptation of spinach chloroplast to different light quality environments. Plant Cell 1:645-654.
114. Deng, Xing-Wang, and Wilhelm Gruissem (1988). Constitutive transcription and regulation of gene expression in non-photosynthetic plastids of higher plants. EMBO J. 7:3301-3308.
115. Deng, Xing-Wang, and Wilhelm Gruissem (1987). Control of plastid gene expression during development: the limited role of transcriptional regulation. Cell 49:378-387.
116. Deng, Xing-Wang, David B. Stern, John C. Tonkyn and Wilhelm Gruissem (1987). Plastid run-on transcription: application to determine the transcriptional regulation of spinach plastid genes. J. Biol. Chem. 262(20):9641-9648.
117. Xing-Wang Deng and Zhenan Mei (1997). the higher plant thylakoid pigment-protein complexes migration and the reduction of light energy distribution between two photosystems. Scientia Sinica (series B) 4, 377-386.
118. Xing-Wang Deng and Anastasios Melis (1996). Phosphorylation of the light-harvesting complex II in higher plant chloroplasts: effect on photosystem II and photosystem I absorption cross section. Photobiochemistry and Photobiophysics 13, 41-52.
119. Xing-Wang Deng and Wilhelm Gruissem (1994). Chloroplast run-on transcription: determination of the transcription activity of chloroplast genes. A chapter on a published laboratory manual based on a COLD SPRING HARBOR COURSE.
120. Anastasios Melis and Xing-Wang Deng (1987). The physiological significance of thylakoid membrane protein phosphorylation. In Progress in Photosynthesis Research, ed. J. Biggins. Vol. II (2):257-260.
121. Wilhelm Gruissem, Xing-Wang Deng, Helen Jones, David Stern, John Tonkyn and Gerald Zurawski (1987). Transcriptional and post-transcriptional regulation of chloroplast gene expression. In Structure and Function of Plant Genome, Von Wettstein D., Chua, N. H. (eds), Plenum Press, New York, pp.135-148.
122. Wilhelm Gruissem, Alice Barkan, Xing-Wang Deng and David Stern (1988). Transcriptional and Post-transcriptional control of plastid mRNA levels in higher plants. Trends in Genetics 4(9), 258-363. 

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