室内装修与小儿哮喘关系的探讨

发布时间：2018-01-21 04:20

本文关键词： 室内装修小儿哮喘免疫球蛋白血嗜酸细胞　出处：《新疆医科大学》2006年硕士论文　论文类型：学位论文

【摘要】：目的：探讨室内装修后的化学性暴露因素与小儿哮喘的发病关系，观测对患者外周血嗜酸性细胞(EOS)和血清IgE、IgA、IgG、IgM、C3、C4的影响作用。方法：依据哮喘诊断标准，按照随机方法，选择患病者61例和对照61例，根据哮喘发作期住院陈述病史中居住环境是否装修分为A1、A2组即(A1)：哮喘装修组30例(A2)：哮喘非装修组30例，健康对照(B1)非哮喘有装修组61例和(B2)哮喘有装修组61例，运用国产ZX-2室内空气质量分析仪分别进行四组家庭居室内空气中甲醛、苯、氨浓度的检测，同时检验各组血液IgE、IgA、IgG、IgM、C3、C4、外周血嗜酸性细胞(EOS)等样本的指标。采用t或秩和检验，以P＜0.05判定为是否有统计学差异。结果：1．血清学指标：血清IgE，，IgA，外周血EOS，A1组明显高于A2、B1和B2组，差异有显著性意义(P＜0.05)。其它各组间无差异，而IgG、IgM、C3、C4未显示统计学意义(P＞0.05)。2．空气指标：室内甲醛、苯、氨浓度A1组＞B1组＞A2和B2组，而A2与B2相近，A1组与A2和B2差别有显著性意义(P＜0.05)，A1组与B2组间无差异。非参数相关分析甲醛、苯和氨与儿童哮喘呈正相关性。结论：装饰材料中—甲醛、苯、氨是室内装修后主要污染物，这些危险因素所造成的室内空气不良，可促使或导致小儿发生哮喘而且增加哮喘发作的频率。可能的机制在于通过影响血清IgE、IgA和外周血嗜酸性细胞(EOS)水平来产生健康危害。A2组哮喘的发生可能与其它因素有关。
[Abstract]:Objective: to investigate the relationship between chemical exposure factors after indoor decoration and asthma in children, and to observe the eosinophilic cells (EOS) in peripheral blood and serum IgE (IgA) and IgM (C 3) in children with asthma. Methods: according to the diagnostic criteria of asthma, 61 cases of patients with asthma and 61 cases of control group were selected according to the criteria of asthma diagnosis, and the living environment was divided into A1 according to the history of hospitalization of asthma attack. A2 group: asthma decoration group (30 cases): asthma group (30 cases), healthy control group (B _ 1) group (61 cases) and group B _ (2) group (61 cases). The concentrations of formaldehyde, benzene and ammonia in the indoor air of four groups were detected by ZX-2 indoor air quality analyzer. C4, eosinophil eosinophilic cells in peripheral blood and other samples. T or rank sum test was used to determine whether there was statistical difference between the two groups (P < 0. 05). Results: 1. Serological index: serum IgE. The level of IgA in EOSA A1 group was significantly higher than that in A 2 B 1 and B 2 groups (P < 0 05), but there was no significant difference among other groups, but IgM C 3 in IgGN group was significantly higher than that in B 2 group (P < 0 05). C4 had no statistical significance (P > 0.05). Air index: indoor formaldehyde, benzene, ammonia concentration A1 > B1 > A2 and B2, but A2 and B2 were similar. There was no significant difference between group A1 and group A2 and B2 (P < 0.05), but there was no difference between group A1 and group B2. Conclusion: formaldehyde, benzene and ammonia are the main pollutants in decoration materials. May cause or cause asthma in children and increase the frequency of asthma attacks. The level of IgA and eosinophilic cells in peripheral blood to produce health hazard. A2 asthma may be related to other factors.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R725.6

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