兔颞下颌关节突缺损模型的建立和CFR-PEEK材料人造关节的修复效果评价

发布时间：2017-12-27 19:19

本文关键词：兔颞下颌关节突缺损模型的建立和CFR-PEEK材料人造关节的修复效果评价　出处：《吉林大学学报(医学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨兔颞下颌关节(TMJ)关节突缺损模型建立后实现关节置换的方法,阐明碳纤维增强型聚醚醚酮(CFR-PEEK)材料制作的TMJ假体的置换修复效果,为临床应用CFR-PEEK人造关节置换TMJ提供实验依据。方法:13只健康成年日本大耳白兔按照随机数字法分为实验组(n=6)、阳性对照组(n=4)和阴性对照组(n=3)。实验组兔切除右侧TMJ关节突,建立关节缺损模型,同期植入CFR-PEEK人造关节;阳性对照组兔切除右侧TMJ关节突,建立关节缺损模型,不植入CFR-PEEK人造关节;阴性对照组兔不做任何处理。通过CT影像学检查评估人造关节植入后的固位和替代修复效果。连续记录13周各组兔体质量并进行比较。结果:建立的兔TMJ关节突缺损模型能够成功植入CFR-PEEK人造关节。CT影像学检查,经三维重建和体外显影处理后可见植入CFR-PEEK人工关节固位良好,代替正常关节发挥作用;13周兔体质量观察,与阳性对照组比较,实验组兔体质量增加(P0.05);实验组和阴性对照组兔体质量均明显增加,但2组比较差异无统计学意义(P0.05)。实验组和阴性对照组兔体质量均正常增长,阳性对照组兔体质量增长较为缓慢,甚至停止增长或者负增长。结论:植入CFR-PEEK人造关节修复关节突缺损能够有效恢复兔正常咀嚼功能,CFR-PEEK人造关节成功应用于TMJ缺损修复,有望成为一种重建TMJ关节突的理想材料。
[Abstract]:Objective: To investigate the temporomandibular joint (TMJ) method to achieve the establishment of facet joint replacement defect model, clarify the carbon fiber reinforced polyetheretherketone (CFR-PEEK) replacement repair effect of TMJ prosthesis materials, and provide the experimental basis for the clinical application of CFR-PEEK artificial joint replacement TMJ. Methods: 13 healthy adult Japanese white rabbits were divided into experimental group (n=6), positive control group (n=4) and negative control group (n=3) according to the random number method. In the experimental group, the right TMJ articular process was removed, and a joint defect model was established. CFR-PEEK artificial joint was implanted at the same time. The right TMJ joint process was removed in the positive control group, and the joint defect model was established, without CFR-PEEK artificial joint, and the negative control group did not do any treatment. CT imaging examination was used to evaluate the retention and replacement effect of artificial joint implantation. The mass of rabbits in each group was recorded for 13 weeks and compared. Results: the model of rabbit TMJ joint defect could be successfully implanted into the artificial joint of CFR-PEEK. CT imaging, the 3D reconstruction and in vitro after developing CFR-PEEK artificial joint implants visible good retention, instead of the normal joint function; 13 weeks of observation Tuti quality, compared with the positive control group, the experimental group increased body weight (P0.05); experimental group and negative control group rabbits body weight were significantly increased. But the difference between the 2 groups was not statistically significant (P0.05). The quality of the rabbits in the experimental group and the negative control group increased normally. The growth of the rabbit body in the positive control group was slower, even stopped growth or negative growth. Conclusion: implantation of CFR-PEEK artificial joint to repair the joint defect can effectively restore the normal masticatory function of rabbits. CFR-PEEK artificial joint has been successfully applied to TMJ defect repair, and is expected to become an ideal material for reconstruction of TMJ articular process.
【作者单位】：吉林大学口腔医院口腔颌面外科;吉林大学口腔医院消毒供应室;吉林大学口腔医院正畸科;
【基金】：吉林省科技厅自然科学基金资助课题(3D515V663431) 吉林省卫计委青年科研基金资助课题(3D514CP23431)
【分类号】：R-332;R782.6
【正文快照】： 聚醚醚酮(polyetheretherketone,PEEK)是一种半晶型芳香族热塑性工程塑料,具有优良的机械性能、热稳定性和环境阻力[1]。PEEK抗压力强,不会因压力变化而发生改变,此外其在弹性、硬度、抗拉强度以及抗腐蚀、磨损和疲劳等方面的性能也很优越,而且材料在人体环境中能够与人体内的

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