天芪益智颗粒对鹅膏蕈氨酸致痴呆大鼠模型抗氧化能力的影响

发布时间：2017-12-28 11:35

本文关键词：天芪益智颗粒对鹅膏蕈氨酸致痴呆大鼠模型抗氧化能力的影响　出处：《中药药理与临床》2017年01期 　论文类型：期刊论文

【摘要】：目的:探讨天芪益智颗粒对痴呆模型大鼠认知功能及抗氧化能力的影响。方法:建立鹅膏蕈氨酸基底核微量注射AD模型。采用Morris水迷宫法检测大鼠的学习记忆能力变化;尼氏染色法检测海马和大脑皮层神经元病理改变;分光度法检测大鼠脑组织MDA、H_2O_2含量及SOD、GR、CAT活力。结果:与模型组相比,天芪益智颗粒0.63g/kg、0.42g/kg剂量组第5d逃避潜伏期明显降低,0.42g/kg剂量组穿越平台次数明显增加,神经元数量增多;与模型组比较,天芪益智颗粒0.63g/kg、0.42g/kg剂量组显著降低MAD、H_2O_2含量及提高GR活力。结论:天芪益智颗粒具有改善模型大鼠认知功能障碍,保护神经细胞的作用,该作用与其增强抗氧化能力有关。
[Abstract]:Objective: To explore the effect of Tianqi Yizhi Granule on cognitive function and antioxidant capacity of dementia model rats. Methods: the microinjection of AD model of funninic funnus funnus basilar nucleus was established. Morris water maze was used to detect the changes of learning and memory in rats. Nissl staining was used to detect the pathological changes in hippocampus and cerebral cortex neurons. The MDA and H_2O_2 contents in rat brain and the activity of SOD, GR and CAT were detected by spectrophotometry. Results: compared with the model group, Tianqi Yizhi granules 0.63g/kg, 0.42g/kg group 5D the escape latency was significantly reduced, the number of cross platform 0.42g/kg dose group increased significantly, the number of neurons increased; compared with the model group, Tianqi Yizhi granules 0.63g/kg, 0.42g/kg dose group significantly decreased MAD and H_2O_2 content and increase the activity of GR. Conclusion: Tianqi Yizi granule can improve the cognitive impairment of model rats and protect the nerve cells. This effect is related to the enhancement of antioxidant capacity.
【作者单位】：四川省中药资源系统研究与开发利用国家重点实验室培育基地;成都中医药大学药学院;北京师范大学认知神经科学与学习国家重点实验室;
【基金】：国家科技重大专项-重大新药创制(2013ZX09103002-002) 四川省学术和技术带头人培养资金资助项(2015058) 中药药理四川省青年科技创新研究团队(2014TD0007)
【分类号】：R285.5;R-332
【正文快照】： 阿尔茨海默病(Alzheimer disease,AD)是一种最常见的神经退行性疾病,记忆障碍与认知功能下降为其主要特征[1]。研究发现氧化应激与AD发病密切相关,机体脂质异常过氧化,导致氧自由基增多,抗氧化酶活性下降,进而造成细胞损伤,引起神经功能障碍[2,3]。天芪益智颗粒由红景天、红芪

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