柞树叶水提物对Ⅱ型糖尿病模型小鼠的治疗作用

发布时间：2017-12-31 13:14

本文关键词：柞树叶水提物对Ⅱ型糖尿病模型小鼠的治疗作用　出处：《蚕业科学》2017年04期 　论文类型：期刊论文

【摘要】：采用高糖高脂膳食加链脲佐菌素诱导制作Ⅱ型糖尿病模型小鼠,研究柞树叶水提物调节糖尿病模型小鼠血糖浓度、改善生命体征和减轻脏器损伤的作用。与模型对照组相比,按照5、15、30 mg/(kg·d)3种剂量灌胃给予柞树叶水提物的糖尿病模型小鼠的体征均有所改善,饮水和摄食量减少,且呈剂量依赖性;试验第4周,3种剂量给药治疗组糖尿病模型小鼠的空腹血糖浓度均显著或极显著降低,胰岛素敏感指数(ISI)显著升高,血清胰岛素(INS)和胰岛素受体β(IRS-β)浓度未见明显变化;3种剂量给药治疗组小鼠肝组织病理变化程度明显减轻,以30 mg/(kg·d)剂量给药治疗组效果最佳。试验结果提示,柞树叶水提物可能通过提高受体对胰岛素的敏感性,改善胰岛素抵抗而发挥降血糖作用,并使肝损伤明显减轻。
[Abstract]:In type 2 diabetes mice model induced by high glucose and high fat diet and STZ, oak leaf water extract on mice blood glucose regulating concentration, improve life quality and reduce organ injury. Compared with the model group, according to 5,15,30 mg/ (kg d) 3 doses of orally administered oak leaves the water extract of the diabetic mice signs were improved, drinking water and food intake decreased in a dose-dependent manner; test for fourth weeks, fasting blood glucose concentration of 3 dose treatment group of diabetic mice decreased significantly, insulin sensitivity index (ISI) significantly increased serum insulin (INS) and insulin receptor beta (IRS- beta) significant changes in concentration was observed; the 3 dose treatment group liver tissue pathological changes were alleviated, with 30 mg/ (kg - D) dose therapy group has the best effect. The experimental results suggest that oak The leaf water extract may improve the sensitivity of the receptor to insulin, improve insulin resistance and play a hypoglycemic effect, and reduce the liver damage.

【作者单位】：辽宁省农业科学院大连生物技术研究所;大连医科大学公共卫生学院;
【基金】：现代农业产业技术体系建设专项(No.CARS-22) 辽宁省科技厅农业攻关计划项目(No.2014209001)
【分类号】：R285.5;R-332
【正文快照】： 柞树是壳斗科栎属(Quercus L.)植物的统称,为落叶或常绿乔木,少数为灌木,具有耐寒、耐旱能力强,适应性广等特点。我国有柞林面积约700万hm2,广泛分布于东北、华北以及内蒙古等地区,资源十分丰富[1-2]。柞树叶富含粗蛋白、粗脂肪、粗纤维、矿物质和维生素等营养成分及单宁、

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