EB病毒免疫逃逸的分子机制

发布时间：2018-01-01 18:40

本文关键词：EB病毒免疫逃逸的分子机制　出处：《微生物学免疫学进展》2016年03期 　论文类型：期刊论文

【摘要】：EB病毒(Epstein-Barr vius,EBV)是一种最广泛的对人类感染的γ疱疹病毒,与人类多种疾病尤其是恶性肿瘤有关。其致病的一个重要条件是能够在人体B细胞中长期潜伏,并且在人体免疫力低下时被激活并增殖,这表明EB病毒存在逃逸宿主细胞免疫的机制。从潜伏期EB病毒基因表达的下调、干扰抗原加工和提呈、调节细胞毒性T细胞(Cytotoxic lymphocyte,CTL)免疫应答、干扰细胞因子的作用、干扰CTL的活动及抑制宿主细胞凋亡、抑制辅助性T细胞1(Helper T cell 1,Th1)免疫应答等方面,对EB病毒免疫逃逸的分子机制作一简要综述。
[Abstract]:Epstein-Barr virus (EBV) is one of the most widespread human-infected herpesvirus. One of the important conditions for the pathogenesis of human diseases, especially malignant tumors, is to be able to lurk in human B cells for a long time, and to be activated and proliferated when human immunity is low. This indicates that EBV has the mechanism of escaping host cell immunity. From the down-regulation of EBV gene expression in incubation period, it interferes with antigen processing and presentation. To regulate the immune response of cytotoxic T lymphocytes, interfere with the action of cytokines, interfere with the activity of CTL and inhibit the apoptosis of host cells. In this paper, the molecular mechanism of EB virus immune escape is briefly reviewed in terms of inhibiting the immune response of helper T cell 1 Helper T cell 1 to Th1.
【作者单位】：南华大学附属第二医院检验科;
【基金】：湖南省科技厅资助项目(2012FJ3103)
【分类号】：R392.11
【正文快照】： EB病毒是一种疱疹DNA病毒,能够在B细胞中建立潜伏感染。当人体免疫力低下时,EB病毒在B细胞内被激活并大量增殖,且在人群中广泛传播。EB病毒对宿主免疫系统的调控与人类多种疾病和肿瘤的发生、发展密切相关[1]。目前,EB病毒如何逃逸人体免疫系统、侵入机体并诱发疾病的机制复杂

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