Wnt和Notch通路在老龄个体骨髓间充质干细胞成骨中的调控

发布时间：2018-01-02 21:19

本文关键词：Wnt和Notch通路在老龄个体骨髓间充质干细胞成骨中的调控　出处：《国际口腔医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：社会老龄化的加剧使老年个体骨损伤修复问题愈发突出,骨髓间充质干细胞(BMSC)是一种与骨代谢再生密切相关的骨髓细胞,其生物学特性(形态、表面特征、细胞周期、端粒酶以及细胞内活性氧簇水平等)以及增殖分化能力在生物体年龄影响下均发生了改变,成骨能力下降,影响了骨损伤的修复速度和质量。探索其中分子机制对改善老龄个体骨损伤康复有至关重要作用。参与调控的信号中,Wnt和Notch近年日益受到关注,二者对老龄BMSC成骨的调控有交互作用。老龄机体的氧化应激反应增加而生长因子生成减少,Wnt通路的转录因子β-catenin与叉头家族转录因子的亲和力增加,不再与T细胞因子和淋巴增强因子结合,故BMSC成骨减弱。同时老龄个体骨髓中BMSC数量减少,Notch抑制BMSC成骨来维持祖细胞池中BMSC的数量。Wnt和Notch之间还存在相互作用,如Notch过表达能够削弱Wnt的影响等。此外,BMP-Smad转录因子活性下降,Hedgehog信号通路下调,亦影响着BMSC的成骨分化。本文对老龄个体BMSC生物学性能变化及其成骨分化过程中信号通路的调控作用进行综述,为老龄个体骨相关性疾病的治疗提供新思路。
[Abstract]:Aging society of the elderly individual bone injury repair problems become more prominent, bone marrow mesenchymal stem cells (BMSC) is a kind of bone metabolism is closely related with the regeneration of bone marrow cells and its biological characteristics (morphology, surface characteristics, cell cycle, telomerase and intracellular active oxygen cluster level) and proliferation changes in organisms under the influence of age, decreased bone ability, affect the speed and quality of bone injury repair. To explore the molecular mechanism of aging individual bone injury rehabilitation has a crucial role. The signal involved in the regulation of Wnt and Notch in recent years, increasing attention, the two have interaction effect on aging BMSC bone the regulation of oxidative stress. The increase of aging body growth factor decreased, increased transcription factor beta -catenin Wnt pathway and the forkhead family transcription factor T and cell affinity, not because The son and lymphoid enhancer factor binding, so BMSC bone decreased. While the number of BMSC aging individual bone marrow decreased, Notch inhibited BMSC osteoblast interaction between BMSC progenitor cell pool to maintain the number of.Wnt and Notch, such as overexpression of Notch can weaken the effect of Wnt. In addition, BMP-Smad decreased the activity of transcription factors Hedgehog signal pathway down, also affect the osteogenic differentiation of BMSC. This paper reviewed the biological properties of the aging individual BMSC change regulation and signaling pathway during the differentiation into bone, to provide new ideas for the treatment of aging individual bone related diseases.

【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院口腔颌面外科;
【基金】：国家自然科学基金(81270421,81571366)~~
【分类号】：R329.2
【正文快照】： 成骨细胞是参与骨生成的主要功能细胞,在骨的生长发育、新陈代谢及修复重建中发挥重要作用。成骨细胞来源于具有多向分化潜能的骨髓间充质干细胞(bone marrow derived mesenchymalstem cell,BMSC)。老龄个体骨骼质量下降,易发生骨损伤且修复较年轻个体困难,与BMSC的增龄性改变

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