肌细胞特异性microRNAs对收缩舒张生物学效应调控机制的研究进展

发布时间：2018-01-10 17:12

本文关键词：肌细胞特异性microRNAs对收缩舒张生物学效应调控机制的研究进展　出处：《复旦学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：肌细胞特异性microRNAs(muscle-specific microRNAs,myomiRs)是一类特异性表达在肌组织中的内源性非编码小分子RNA,通过转录后水平负调控相关基因的表达,广泛参与到一系列生物学过程中,影响疾病的发生发展。肌细胞相关疾病(如慢性阻塞性肺炎、肥厚型心肌病等)的发生、发展可引起myomiRs及其下游靶基因表达改变,从而进一步影响疾病的发展、预后及转归。本文将综述miR-1、miR-133、miR-206、miR-208和miR-499等常见myomiRs在横纹肌和非横纹肌收缩舒张机制中的作用,重点关注myomiRs对肌细胞收缩舒张生物学效应的影响,以期为肌细胞相关疾病治疗提供新思路。
[Abstract]:Myocyte specific microRNAs(muscle-specific microRNAs. MyomiRsis a kind of endogenous non-coding small molecule RNAs which is specifically expressed in muscle tissue. It is involved in a series of biological processes through the expression of genes related to negative regulation at post-transcriptional level. The occurrence and development of myocyte related diseases (such as chronic obstructive pneumonia, hypertrophic cardiomyopathy, etc.) may cause changes in the expression of myomiRs and its downstream target genes. This will further influence the development, prognosis and outcome of the disease. This article will review miR-1 miR-133 miR-206. The role of common myomiRs, such as miR-208 and miR-499, in the contractile and diastolic mechanisms of striated and non-striated muscles. Focus on the effects of myomiRs on the biological effects of myocyte contraction and relaxation in order to provide new ideas for the treatment of myocyte related diseases.
【作者单位】：上海中医药大学上海市针灸经络研究所;
【基金】：国家自然科学基金(81473760,81574058) 上海市人才发展基金(201610) 上海市卫生系统优秀青年人才培养计划(XYQ2013081) 上海市中医药事业发展三年行动计划重大研究项目(ZY3-CCCX-3-3005)~~
【分类号】：R363
【正文快照】： *This work was supported by the National Natural Science Foundation of China(81473760,81574058),Shanghai TalentDevelopment Fund(201610),Training Plan for the Excellent Youth Scholars of Shanghai Health System(XYQ2013081)and theThree-year Action Plan for

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