免疫细胞相关的能量代谢

发布时间：2018-01-10 19:10

本文关键词：免疫细胞相关的能量代谢　出处：《生命科学》2016年02期 　论文类型：期刊论文

【摘要】："免疫细胞的代谢及其调节"是近年发展而成的一个新研究领域。大量实验研究证实,免疫应答通常伴随某些免疫细胞在短时间内大量增殖、激活,而活化的免疫细胞(如T细胞/B细胞及其功能亚群、不同类型的固有免疫细胞等)有赖于改变其能量代谢方式而分化、扩增及发挥功能。因此,通过调控免疫细胞的能量代谢方式,可影响免疫应答的产生、效应及转归,并干预某些免疫病理过程的发生和发展。主要介绍不同T细胞亚群、B细胞和固有免疫细胞(如i NKT细胞等)的能量代谢及其调节,以及调控能量代谢对免疫细胞(尤其是T细胞)分化、功能的影响及其机制。
[Abstract]:"Metabolism and regulation of immune cells" is a new research field developed in recent years. A large number of experimental studies have confirmed that immune response is usually accompanied by a large number of proliferation and activation of some immune cells in a short period of time. The activated immune cells (such as T cell / B cells and their functional subsets, different types of innate immune cells, etc.) depend on changing their energy metabolism to differentiate, expand and function. By regulating the energy metabolism of immune cells, it can affect the generation, effect and outcome of immune response, and interfere with the occurrence and development of some immune pathological processes. The energy metabolism and regulation of B cells and innate immune cells (such as I NKT cells), and the effects of energy metabolism on the differentiation and function of immune cells (especially T cells) and its mechanism.
【作者单位】：华中科技大学同济医学院基础医学院免疫学系;
【基金】：国家自然科学基金项目(31470851,31570913,81571548)
【分类号】：R392.12
【正文快照】： “代谢”指机体摄取营养物质后的全部物理和化学反应过程,包括营养物质转化、合成、降解以及能量转换及废物排出等。机体通过分解代谢和合成代谢提供能量并合成生物大分子,从而维持生存及生命活动的需要。人们早已认识到营养不良与免疫缺陷相关[1],但长期以来“免疫”与“代谢

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