炎症因子chemerin在肥胖及其相关疾病中的作用及运动对chemerin调控的研究进展

发布时间：2018-01-16 09:37

本文关键词：炎症因子chemerin在肥胖及其相关疾病中的作用及运动对chemerin调控的研究进展　出处：《生理科学进展》2017年05期 　论文类型：期刊论文

更多相关文章： chemerin 肥胖及其相关疾病 运动 PPARγ

【摘要】：作为一个脂肪和炎症因子,chemerin与肥胖及其相关疾病如2型糖尿病、代谢综合征、动脉粥样硬化等疾病的发生和严重程度密切相关。运动是防治肥胖及其相关疾病、改善其紊乱的糖脂代谢的有效方法;该作用与运动通过过氧化物增殖因子活化受体(PPARγ)的激活来降低肥胖及其相关疾病的血清、脂肪、肝和骨骼肌的chemerin水平有关。chemerin的降低一方面减轻炎症,另一方面改善糖脂代谢,从而防治肥胖及其相关疾病。本文就chemerin概况、其在肥胖及其相关疾病中的作用,以及运动对chemerin的调控及机制做一综述。
[Abstract]:As a fat and inflammatory factor chemerin is associated with obesity and related diseases such as type 2 diabetes and metabolic syndrome. The occurrence and severity of atherosclerosis and other diseases are closely related. Exercise is an effective method to prevent and treat obesity and related diseases and improve its disorder of glucose and lipid metabolism. This effect is associated with exercise through the activation of the peroxide proliferator activated receptor (PPAR 纬) to reduce the serum and fat levels of obesity and related diseases. The level of chemerin in liver and skeletal muscle is related to the decrease of. Chemerin on the one hand to alleviate inflammation, on the other hand to improve the metabolism of glucose and lipid. In this paper, the general situation of chemerin, its role in obesity and related diseases, and the regulation and mechanism of exercise on chemerin are reviewed.
【作者单位】：上海体育学院运动科学学院;
【基金】：上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)资助课题
【分类号】：R363
【正文快照】： 肥胖及其相关疾病如代谢综合征、糖尿病、冠心病、动脉粥样硬化和高血压已成为人类死亡的首位原因。对肥胖及其相关疾病发生机制的认识,低度炎症学说是目前的研究热点之一。作为一种系统性的慢性低度炎症,肥胖及其相关疾病最显著的特征表现为两方面,一是脂肪、肝、骨骼肌等全

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