盐炙杜仲对衰老性骨质疏松模型大鼠血生化指标的影响

发布时间：2018-01-19 14:42

本文关键词： 杜仲衰老性骨质疏松血生化指标 BMD　出处：《时珍国医国药》2016年11期 　论文类型：期刊论文

【摘要】：目的通过建立D-半乳糖致衰老性骨质疏松(SOP)大鼠模型,探讨盐炙杜仲治疗SOP在血生化指标的影响。方法将60只雄性SD大鼠随机分为6组,除了空白对照组外,其他五组均给予腹腔注射D-半乳糖;空白对照组给予腹腔注射同等剂量的生理盐水。8周后造模成功,空白对照组、模型对照组均给予0.5%CMC-Na液灌胃;阳性对照组给予依替膦酸钠灌胃;YL组给予盐炙杜仲低剂量灌胃;YM组给予盐炙杜仲中剂量灌胃;YH组给予盐炙杜仲高剂量灌胃。各组连续给药4周后,采血取材检测血生化指标及BMD测定。结果 YH组血清Ca2+出现了显著的减少,具有统计学意义(P0.05);YH组血清ALP数值较对照组显著升高,具有统计学意义(P0.01);高剂量和中剂量杜仲具有显著的升高血清IGF-I的作用(P0.05和P0.01)。结论实验证明盐炙杜仲能够降低血钙,提高血清ALP和IGF-I活性,促进钙盐沉积,有利于治疗SOP。
[Abstract]:Objective to establish a rat model of aging osteoporosis induced by D-galactose and to explore the effect of salt-broiled Eucommia ulmoides ulmoides on blood biochemical indexes. Methods 60 male SD rats were randomly divided into 6 groups. In addition to the blank control group, the other five groups were given intraperitoneal injection of D-galactose; The model was successfully established in the blank control group after intraperitoneal injection of the same dose of normal saline for 8 weeks. The model control group and the model control group were all given 0.5% CMC-Na solution. The positive control group was given intragastric administration of etedronate; YL group was treated with salt-broiled Eucommia ulmoides at low dose. YM group was treated with salt-broiled Eucommia ulmoides. YH group was given high dose of salt broiled Eucommia ulmoides. After 4 weeks of continuous administration, blood samples were collected to detect the biochemical indexes and BMD. Results the serum Ca2 of YH group decreased significantly. It has statistical significance (P0.05). The serum ALP in YH group was significantly higher than that in the control group (P 0.01). High and medium doses of Eucommia ulmoides could significantly increase serum IGF-I (P0.05) and P0.01.Conclusion Salt-broiled Eucommia ulmoides can reduce serum calcium. The activities of serum ALP and IGF-I were increased, and calcium salt deposition was promoted, which was beneficial to the treatment of SOP.
【作者单位】：武汉市中西医结合医院;武汉市中医医院;
【基金】：湖北省武汉市卫计委项目(WZ16D01)
【分类号】：R285.5;R-332
【正文快照】： 原发性骨质疏松症主要分为绝经后骨质疏松症(Ⅰ型)和老年性骨质疏松症(Ⅱ型)。绝经后骨质疏松被国内外学者广泛研究,并且世界卫生组织(WHO)已经确定了去卵巢大鼠是研究绝经后骨质疏松症的最佳模型[1]。然而,由于老年性骨质疏松症(SOP)是生物衰老在骨骼方面的一种特殊表现,且复

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