戴氏绿僵菌多糖对糖尿病模型小鼠血糖和免疫功能的影响

发布时间：2018-01-22 19:11

本文关键词： 戴氏绿僵菌多糖糖尿病模型链脲佐菌素　出处：《中国免疫学杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的:探讨戴氏绿僵菌多糖对糖尿病模型小鼠血糖和免疫功能的影响。方法:采用连续多次小剂量腹腔注射链脲佐菌素(STZ)建立Ⅰ型糖尿病模型,观察模型小鼠体重变化,检测空腹血清葡萄糖,免疫器官(脾脏、胸腺)指数,腹腔巨噬细胞吞噬能力,脾淋巴细胞增殖及血清中免疫球蛋白Ig G、补体C3、C4的含量等。结果:戴氏绿僵菌多糖能够改善模型小鼠体重;降低模型小鼠血糖含量,中、高剂量的多糖均能显著提高模型小鼠T、B淋巴细胞的增殖能力(P0.01);高剂量能显著提高模型小鼠脾脏指数和血清中Ig G、C3、C4的含量(P0.01);中、高剂量能显著提高模型小鼠胸腺指数及腹腔巨噬细胞吞噬能力(P0.01)。结论:戴氏绿僵菌多糖可增强STZ诱导的Ⅰ型糖尿病模型小鼠的免疫功能和降低Ⅰ型糖尿病模型小鼠血糖含量。
[Abstract]:Objective: to investigate the effect of Metarhizium dahlinii polysaccharides on blood glucose and immune function in diabetic mice. Methods: the model of type I diabetes was established by continuous intraperitoneal injection of streptozotocin (STZ) with multiple doses of streptozotocin (STZ). The changes of body weight, fasting serum glucose, index of immune organs (spleen, thymus), phagocytosis of peritoneal macrophages, proliferation of spleen lymphocytes and immunoglobulin G in serum were observed. Results: Metarhizium dahlii polysaccharides could improve the body weight of the model mice. Reducing the blood sugar content of the model mice, the medium and high dose of polysaccharides could significantly increase the proliferation ability of TnB lymphocytes in the model mice. High dose could significantly increase the spleen index of model mice and the content of Ig GfC _ 3C _ 4 in serum (P _ (0.01)). Middle. The thymus index and phagocytosis of peritoneal macrophages were significantly increased by high dose (P0.01). Conclusion: Metarhizium dahllii polysaccharides can enhance the immune function and decrease the blood glucose content of type 1 diabetic mice induced by STZ.
【作者单位】：遵义医学院附属医院医学检验科;遵义医学院附属医院转化医学中心;遵义医学院医学遗传学教研室;遵义医学院检验系;
【分类号】：R285.5
【正文快照】： 1本文为贵州省科技厅基金(黔科合J字[2009]2148号)和贵州省科技厅联合基金(黔科合J字LKZ[2011]35号)项目。2遵义医学院附属医院转化医学中心,遵义563000。虫草是一种稀有的药用真菌,在食品、医药卫生等领域具有重要价值的真菌资源,我国是世界上虫草分布最多的国家,前期研究表

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