细胞生长因子微环境与早期胚胎发育

发布时间：2018-01-30 00:44

本文关键词： 胚胎发育表皮生长因子胰岛素样生长因子Ⅰ 组织构建组织工程白细胞抑制因子胰岛素样生长因子胚胎细胞凋亡　出处：《中国组织工程研究》2016年11期 　论文类型：期刊论文

【摘要】：背景:哺乳动物胚胎早期发育和着床是一个非常复杂的过程,受到多种细胞因子的调节,其中表皮生长因子、转化生长因子、白血病抑制因子、胰岛素样生长因子和血管内皮生长因子在调控此过程中发挥着重要的作用。目的:介绍影响早期胚胎发育的相关细胞因子种类、结构特点和分子调控机制,同时,对国内外关于表皮生长因子、转化生长因子、白血病抑制因子、胰岛素样生长因子和血管内皮生长因子在早期胚胎发育中的作用研究进展进行了综述。方法:以检索词"胚胎发育(embryos development),表皮生长因子(Epidermal growth factor),胰岛素样生长因子(1nsulin-like growth factor-II),白血病抑制因子(leukemia inhibitory factor),转化生长因子(Transforming growth factor)和血管内皮生长因子(Vascular endothelial growth factor)"检索1989至2015年相关文献。归纳总结近几年文献报道综述5种细胞因子表皮生长因子、转化生长因子、白血病抑制因子、胰岛素样生长因子和血管内皮生长因子对于克服哺乳动物早期胚胎发育阻滞发挥的积极作用。结果与结论:(1)细胞生长因子参与胚胎发育是研究的重点。胰岛素样生长因子能够促进胚胎的生长,表皮生长因子在胚胎发育方面表现出多种形式的功能,白血病抑制因子直接影响卵母细胞发育,孕激素可上调白血病抑制因子表达为胚胎发育提供了良好的细胞因子微环境,血管内皮生长因子促进卵母细胞的体外成熟在胚胎发育的各个阶段都起着非常重要的作用。(2)弄清这些细胞因子的调控模式,不但可以有助于胚胎的体外培养,也有助于减少胚胎凋亡,对促进胚胎发育有十分重大的意义。
[Abstract]:Background: early embryonic development and implantation in mammals is a very complex process, which is regulated by a variety of cytokines, including epidermal growth factor, transforming growth factor, leukemia inhibitory factor. Insulin-like growth factor and vascular endothelial growth factor play an important role in the regulation of this process. Objective: to introduce the types, structural characteristics and molecular regulation mechanism of cytokines affecting the development of early embryos. At the same time, at home and abroad on the epidermal growth factor, transforming growth factor, leukemia inhibitory factor. The role of insulin-like growth factor and vascular endothelial growth factor in early embryonic development was reviewed. Embryos development. Epidermal growth factor. Insulin like growth factor 1 nsulin-like growth factor-II. Leukemia inhibitory factor. Transforming growth factor and vascular endothelial growth factor. Vascular endothelial growth factor. "Retrieval of relevant literature from 1989 to 2015. Five kinds of cytokines epidermal growth factors were summarized and summarized in recent years. Transforming growth factor, leukemia inhibitory factor. The positive role of insulin-like growth factor and vascular endothelial growth factor in overcoming the developmental block of mammalian early embryo. Results and conclusion: 1). The role of cytokines in the development of embryos is very important. Insulin-like growth factors can promote the development of embryos. Epidermal growth factor (EGF) has a variety of functions in embryonic development, and leukemia inhibitory factor directly affects oocyte development. Progesterone can upregulate the expression of leukemia inhibitory factor and provide a good cytokine microenvironment for embryonic development. Vascular endothelial growth factor (VEGF) promotes the maturation of oocytes in vitro and plays a very important role in all stages of embryonic development. It can not only help embryo culture in vitro, but also reduce embryo apoptosis, which is of great significance to promote embryo development.
【作者单位】：泸州医学院附属医院生殖医学技术部;
【分类号】：R321
【正文快照】： 文章快速阅读:早期胚胎发育的相关细胞因子种类、结构特点和分子调控机制这些过程不仅要具体通过细胞间和组织间无脊椎动物的胚胎发育与脊椎的相互作用,而且还必须具备一定的环境动物相同处:也是按阶段循序进条件才能实现,如光照、干旱和寒冷对胚行生物合成和细胞分化;由组织

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