腺苷及其受体在生殖系统的研究进展

发布时间：2018-01-31 06:55

本文关键词： 腺苷腺苷受体生殖系统　出处：《中华生殖与避孕杂志》2017年01期 　论文类型：期刊论文

【摘要】：腺苷是一种内生性核苷,由腺嘌呤和核酸糖组成,广泛分布于哺乳动物各个组织中。细胞内的前体腺嘌呤核苷酸如三磷酸腺苷(adenosine 5'-triphosphate,ATP)、二磷酸腺苷(adenosine 5'-diphosphate,ADP)和单磷酸腺苷(adenosine 5'-monophosphate,AMP)等经核苷磷酸水解酶和5'-外核苷酸酶水解为腺苷,并经腺苷转运载体分泌于胞外,腺苷及其受体在体内发挥着至关重要的作用,如在神经系统和呼吸系统中等。在生殖系统中腺苷及其受体与阴茎勃起功能和精子活力有关;调节睾丸细胞分泌;在输精管中发挥神经样调节作用;调节附睾和前列腺平滑肌收缩;参与调节卵巢细胞内分泌和卵母细胞成熟;调节输卵管细毛运动和子宫平滑肌舒缩;调节胎盘血流量等。本文就腺苷及其受体在生殖系统的表达及作用作一综述。
[Abstract]:Adenosine is an endogenous nucleoside, consisting of adenine and ribose, widely distributed in various tissues in mammals. The intracellular precursor of adenine nucleotides such as adenosine triphosphate (adenosine, 5'-triphosphate, ATP), two AMP (adenosine 5'-diphosphate, ADP) and adenosine monophosphate (adenosine 5'-monophosphate, AMP) by nucleoside hydrolase and phosphate 5'- nucleotide hydrolysis to adenosine by adenosine transporter, and secreted to the extracellular, adenosine and its receptors play a crucial role in the body, such as in the nervous system and respiratory system of medium. In the reproductive system of adenosine and its receptors and erectile function and sperm motility; regulation of testicular cell secretion; play neuronal regulation role in the vas deferens epididymis and prostate smooth muscle contraction; regulation; participate in the regulation of ovarian endocrine cells and oocyte maturation; regulating the fallopian tube fine Mao Yundong and uterine smooth muscle contraction and contraction; regulate placental blood flow and so on. This article reviews the expression and role of adenosine and its receptor in the reproductive system.

【作者单位】：南昌大学江西医学院;
【正文快照】： Drury和Szent-Gy?rgyu在1929年最先提出腺苷是作为调节冠状动脉血管紧张的一种生理性调节器[1],直到1970年Sattin和Rall指出[2],腺苷的细胞调节功能是通过细胞表面特异受体完成的。1978年Burnstock等[3],正式提出了嘌呤受体,并根据他们的药理性质和分子克隆技术将嘌呤受体分为

【相似文献】