ROS调节mTOR信号通路参与自噬的研究进展

发布时间：2018-02-01 05:47

本文关键词： 活性氧类哺乳动物雷帕霉素靶蛋白自噬　出处：《临床心血管病杂志》2016年12期 　论文类型：期刊论文

【摘要】：自噬是真核细胞中普遍存在的一种物质降解途径,通过自噬溶酶体介导,清除自身多余或受损的细胞器,参与正常细胞内稳态的维护,对机体生长、发育和衰老均起重要作用。哺乳动物雷帕霉素靶蛋白(mTOR)是一种丝/苏氨酸蛋白质激酶,接受并整合细胞内外的各种信号,是调节蛋白质翻译与细胞生长等多种生理活动的中心信号分子。而活性氧类(ROS)作为第2信使分子,可介导多种细胞信号通路并发挥广泛的生理效应。研究发现,在自噬的过程中,ROS可通过一定的途径激活或抑制mTOR通路,但其调节机制极其复杂。本文就自噬过程中ROS与mTOR之间相互调节机制的研究进展进行综述。
[Abstract]:Autophagy is a common pathway of substance degradation in eukaryotic cells. Autophagy mediated by lysosome clears its own superfluous or damaged organelles and participates in the maintenance of homeostasis and growth of normal cells. Mammalian rapamycin target protein mTORis a serine / threonine protein kinase that receives and integrates various signals within and outside the cell. Ros is the central signal molecule regulating many physiological activities, such as protein translation and cell growth, while Ros is the second messenger molecule. Ros can mediate many cell signaling pathways and play a wide range of physiological effects. It has been found that Ros can activate or inhibit mTOR pathway through certain pathways during autophagy. However, the regulation mechanism of ROS and mTOR is very complicated. In this paper, the mechanism of interaction between ROS and mTOR in autophagy is reviewed.
【作者单位】：九江学院附属医院心内科;南昌大学研究生院医学部;九江学院基础医学院;
【分类号】：R392
【正文快照】： 自噬是一种高度保守的代谢过程。细胞自噬依赖溶酶体途径,对细胞内衰老、损坏的长寿蛋白或细胞器进行降解,其降解产物可以给那些处于饥饿或代谢压力状态下的细胞提供能量,是细胞处于不利条件的一种自我保护的重要机制[1]。活性氧类(reactive oxygen species,ROS)是在生物体内

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