中国广西人群miRNA-17-92基因簇启动子区rs1491034和rs982873遗传多态性研究

发布时间：2018-02-10 14:36

本文关键词： 多基因族启动区(遗传学) 多态现象遗传大陆人口群　出处：《福建医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的研究rs1491034和rs982873单核苷酸多态性(SNPs)在广西人群中的分布特点,比较二者基因型和等位基因在不同种族、地区人群间的分布差别。方法采用SNaPshot SNP分型技术和DNA测序法检测397例广西人群rs1491034和rs982873SNPs,比较两位点基因型和等位基因频率与国际人类基因组单体型图(HapMap)计划公布的不同种族和地区人群间的差别。结果广西人群rs1491034和rs982873均存在TT,CT及CC 3种基因型。2个位点的基因型和等位基因频率在广西人群不同性别间比较,差别均无统计学意义(P0.05)。广西人群rs1491034基因型和等位基因频率与HapMap-CEU和HapMap-YRI人群比较,差别均有统计学意义(P0.01),而rs982873基因型和等位基因频率与HapMap-JPT和HapMap-YRI人群比较,差别均有统计学意义(P0.05),但两位点基因型和等位基因频率与其他人群比较,差别均无统计学意义(P0.05)。结论广西人群存在rs1491034和rs982873多态性,与其他种族、地区人群比较存在不同程度的差别。
[Abstract]:Objective to study the distribution of rs1491034 and rs982873 single nucleotide polymorphisms (SNPs) in Guangxi population and compare their genotypes and alleles in different races. Methods SNaPshot SNP typing and DNA sequencing were used to detect rs1491034 and rs982873 SNPs in Guangxi population. The genotypes and alleles frequencies of the two loci were compared with those published by the International Human Genome haplotype Map (HapMap) project. Results there were three genotypes of TTCT and CC in rs1491034 and rs982873 of Guangxi population. The genotypes and alleles frequencies of the two loci were compared among different genders in Guangxi population. The frequencies of rs1491034 genotype and allele in Guangxi population were significantly different from those in HapMap-CEU and HapMap-YRI population, but the frequencies of rs982873 genotype and allele in Guangxi population were significantly higher than those in HapMap-JPT and HapMap-YRI population. The differences were statistically significant (P 0.05), but the frequencies of genotype and allele of the two loci were not significantly different from those of other populations. Conclusion there are rs1491034 and rs982873 polymorphisms in Guangxi population, which are similar to those of other ethnic groups. There are different degrees of difference in regional population comparison.
【作者单位】：右江民族医学院附属医院检验科;
【基金】：国家自然科学基金(81560552;81260234) 广西高校重点实验室开放课题(kfkt20160064) 广西研究生教育创新计划项目(201601009)
【分类号】：R394

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