内质网应激中Caspase-12的核心作用

发布时间：2018-02-14 05:53

本文关键词： 未折叠蛋白反应内质网应激 Caspase- 细胞凋亡　出处：《基因组学与应用生物学》2017年09期 　论文类型：期刊论文

【摘要】：内质网(ER)是细胞中一个重要的细胞器,主要功能是脂质的合成、储存以及蛋白质的折叠、加工等。因此,严格调控和维持内质网稳态是至关重要的。在缺氧、Ca~(2+)稳态发生紊乱或者在机体需求和蛋白质折叠装置能力不平衡等情况下都会引起内质网应激(ERS),此时内质网会启动了细胞的一个适应性反应,这种反应被称之为未折叠蛋白反应(UPR)。结果,定位于内质网的分子伴侣被诱导,蛋白质的合成会减缓,与此同时蛋白质的降解系统也会启动。如果内质网应激不能被缓解,细胞凋亡将随之发生。本综述分析了由内质网应激所引起的未折叠蛋白反应信号通道,以及Caspase-12在内质网凋亡途径中的核心作用。这为细胞凋亡的研究提供了一个新的角度,对肿瘤等疾病的治疗提供了一定的理论依据。
[Abstract]:Endoplasmic reticulum (ERR) is an important organelle in cells. Its main functions are lipid synthesis, storage and protein folding and processing. Strict regulation and maintenance of endoplasmic reticulum homeostasis is essential. Disturbance of homeostasis or imbalance of the body's requirements and the ability of protein folding devices can lead to ER stress when endoplasmic reticulum (ER) will occur. Activated an adaptive response of the cell, This reaction is called an unfolded protein reaction. As a result, molecular chaperones located in the endoplasmic reticulum are induced, and protein synthesis slows down, at the same time the protein degradation system is activated. If endoplasmic reticulum stress is not alleviated, This review analyzes the signal pathway of unfolded protein response induced by endoplasmic reticulum stress and the central role of Caspase-12 in the endoplasmic reticulum apoptosis pathway, which provides a new perspective for the study of apoptosis. It provides a certain theoretical basis for the treatment of cancer and other diseases.
【作者单位】：西华师范大学生命科学学院;
【基金】：中国博士后基金(2013M540391) 四川省教育厅重大培育项目(13CZ0029) 三峡库区生态环境与生物资源省部共建重点实验室开放课题基金项目(SKL-2011-05)共同资助
【分类号】：R3416

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