Ghrelin如何参与骨代谢:理论研究的最新进展与现状

发布时间：2018-02-25 03:11

本文关键词： Ghrelin 骨和骨组织组织工程组织构建骨组织工程骨代谢促生长激素分泌素受体　出处：《中国组织工程研究》2017年12期 　论文类型：期刊论文

【摘要】：背景:Ghrelin是最近在人及大鼠胃部发现的一种脑肠肽。作为促生长激素分泌物受体的内源性配体,Ghrelin能强烈刺激生长激素的释放。尽管促生长激素分泌素受体在众多外周组织中有表达,但是很少有人知道关于Ghrelin对骨代谢的影响以及促生长激素分泌素受体在骨组织中的表达。目的:对Ghrelin参与骨代谢的研究进展进行综述。方法:第一作者以"Ghrelin,骨代谢"检索CNKI数据库、万方数据库,以"Ghrelin,Bone metabolism"检索Pub Med数据库、Springerlink数据库。纳入有关Ghrelin以及参与骨代谢的研究,排除重复研究。通过阅读摘要初步筛选,共选取53篇文献进行分析。结果与结论:Ghrelin是在小鼠和人的胃内分泌细胞及下丘脑弓状核发现的一种含有28个氨基酸残基的多肽,其对消化系统、神经系统、免疫系统以及内分泌系统影响较大,同时,Ghrelin在激素分泌、糖代谢、免疫、细胞增殖、炎症等许多方面均有作用。血Ghrelin对骨的生长、发育具有一定影响,对成骨细胞的影响主要表现为促进其增殖分化,抑制其凋亡。通过减少Runx2蛋白的表达量抑制C3H10T1/2细胞早期成骨分化,并能通过降低PPARγ2的表达而减弱成脂分化,促进成骨分化。但促生长激素分泌素受体在骨组织中的表达研究报道较少。
[Abstract]:Background: ghrelin is a recently discovered brain-gut peptide in human and rat stomach. Ghrelin, an endogenous ligand of growth hormone secretion receptor, can strongly stimulate the release of growth hormone, although the growth hormone secretin receptor is in many ways. There is expression in the tissues around the week. But few people know about the effect of Ghrelin on bone metabolism and the expression of growth hormone secretin receptor in bone tissue. Objective: to review the research progress of Ghrelin involved in bone metabolism. To retrieve the CNKI database, Wanfang database, which is used to retrieve the Pub Med database Springerlink database with "ghrelin bone metabolism". The research on Ghrelin and its involvement in bone metabolism is included, and repeated studies are excluded. Results and conclusion: a total of 53 articles were selected for analysis. Results and conclusion: ghrelin is a peptide containing 28 amino acid residues found in mouse and human gastric endocrine cells and hypothalamic arcuate nucleus, which affects the digestive system and nervous system. At the same time, ghrelin plays an important role in hormone secretion, glucose metabolism, immunity, cell proliferation, inflammation and so on. Blood Ghrelin has a certain effect on the growth and development of bone. The effect on osteoblasts was mainly to promote the proliferation and differentiation of osteoblasts and inhibit their apoptosis. By reducing the expression of Runx2 protein, the early osteogenic differentiation of C3H10T1 / 2 cells was inhibited, and the adipogenic differentiation of C3H10T1 / 2 cells was weakened by decreasing the expression of PPAR 纬 2. But there are few reports on the expression of growth hormone secretin receptor in bone tissue.
【作者单位】：上海市徐汇区凌云社区卫生服务中心;同济大学附属杨浦医院;
【分类号】：R336

【相似文献】