白酒对大鼠血脂及脂代谢关键酶影响的研究

发布时间：2018-02-26 21:17

本文关键词： 浓香型白酒大鼠血脂脂代谢　出处：《现代预防医学》2017年22期 　论文类型：期刊论文

【摘要】：目的观察2种浓香型白酒对大鼠血脂及脂代谢关键酶的影响,分析不同酒样对脂代谢影响的差异,探讨适量饮酒调节机体脂代谢的可能机制。方法 105只雄性SD大鼠随机分为7组,分别为1-1、1-2、1-3、2-1、2-2、2-3和对照组,按低、中、高剂量分别灌服2种浓香型白酒,连续灌胃8周,检测大鼠肝功、血脂及脂肪分解、合成关键酶水平,对比组间差异。结果 AST水平1-3、2-1、2-2组较对照组有降低(P0.05);与对照组相比,1-2组ATGL升高(P0.05),且酒样1的3个剂量组分别高于酒样2的3个剂量组(P0.05);2-1、2-3组HSL升高(P0.05),且2-1组高于1-1组(P0.05);酒样2的3个剂量组CPT-I水平均降低(P0.05),1-1、1-2组分别高于2-1、2-2组;酒样组的ACO水平和DCAT水平较对照组分别升高(P0.05)和降低(P0.05);2-2组FAS水平低于对照组(P0.05)。结论适量浓香型白酒可提高部分脂肪分解关键酶水平,同时降低脂肪合成关键酶水平,这可能是适量饮酒对机体脂代谢调节的机制之一,这种调节作用可能与饮酒品质相关。
[Abstract]:Objective to observe the effects of two kinds of Luzhou-flavor liquor on blood lipids and key enzymes of lipid metabolism in rats, and to analyze the difference of the effects of different liquor samples on lipid metabolism. Methods 105 male Sprague-Dawley rats were randomly divided into 7 groups: 1-1D 1-2N 1-3O2-1O2-2O2-3 and control group. Two kinds of Luzhou-flavor liquor were administered at low, medium and high doses respectively for 8 weeks. Liver function, lipids, lipid decomposition and synthesis of key enzymes were measured in rats. Results compared with the control group, the level of AST in groups 1-3 and 2-1 was lower than that in the control group (P 0.05), and the levels of ATGL in group 1 and 2 were higher than those in group 1, and the levels of HSL in group 2 were higher than those in group 2 (P 0.05) and higher than that in group 1 (P < 0.01). The levels of CPT-I in the three dosage groups of alcohol sample 2 were significantly lower than those in the control group (P 0.05) and the control group (P < 0.05), and the levels of CPT-I in the two groups were significantly higher than those in the control group (P < 0.05). Compared with the control group, the levels of ACO and DCAT in the liquor sample group were higher than those in the control group (P 0.05) and the level of FAS in the control group was lower than that in the control group. Conclusion moderate amount of Luzhou-flavor liquor can increase the level of some key lipolytic enzymes and decrease the level of fat synthesis key enzymes. This may be one of the mechanisms of moderate alcohol consumption regulating lipid metabolism, which may be related to drinking quality.
【作者单位】：四川大学华西公共卫生学院(华西第四医院);重庆市渝中区疾病预防控制中心;四川省酿酒研究所;
【基金】：四川省科技厅资助项目(编号:2014JY0216)
【分类号】：R-332

【相似文献】