冠状动脉递推建模及其应用

发布时间：2018-02-28 07:11

本文关键词： 冠状动脉血管切向运动 X射线造影三维重建模型更新递推建模模型应用　出处：《华中科技大学》2011年硕士论文　论文类型：学位论文

【摘要】：近年来,心血管疾病的发病率直线上升,已成为人类健康的主要杀手。在我国,由于人口老龄化与人口增长等问题,心血管疾病增长趋势尤为显著。随着计算机辅助治疗技术的不断发展与深入研究,通过二维图像中提取出三维信息的心血管建模为疾病的诊断与治疗提供了新的解决途径。根据医学和生理学的研究成果,本文提出了一种用于X射线血管造影的人体冠状动脉血管的递推建模方法。文中首先利用数字人心脏切片构建心脏和冠状动脉血管三维静态模型,然后同时添加心脏表面法线方向和切线方向的运动来建立它们的三维动态模型,接着比较由不同个体的实际单臂X射线造影图动态重建出的冠状动脉三维血管树与冠脉血管模型的血管分布,当两者的分布差异较大时,则将该重建结果作为新的具有特异性的冠脉血管模型,反之,则融合两者,以获得更具共性的一般化冠脉血管模型,最后,添加更新后结果进冠脉模型库。本文方法可以通过递推的方式不断增强模型库的适用性和完整性,从而为临床治疗或研究提供客观的指导和参考。此外,文章末尾还介绍了动态模型在三维重建中关于匹配和心脏运动补偿方面的应用,并利用冠状动脉血管模型做单臂X射线造影系统模拟实验,验证了心脏运动补偿算法的有效性。
[Abstract]:In recent years, the incidence of cardiovascular disease has increased rapidly and has become the main killer of human health. In China, due to the aging population and population growth, the growth trend of cardiovascular disease is particularly significant. With the development and further research of computer-aided therapy technology, cardiovascular modeling, which extracts three-dimensional information from two-dimensional images, provides a new solution for the diagnosis and treatment of diseases. According to the research results of medicine and physiology, This paper presents a recursive modeling method of human coronary artery for X-ray angiography. In this paper, the three-dimensional static model of heart and coronary artery is constructed by digital human heart slice, and then the three-dimensional dynamic model is built by adding the movement of normal direction and tangent direction of the heart surface at the same time. Then we compare the vascular distribution between the three-dimensional coronary artery tree and the coronary artery model dynamically reconstructed from the actual single-arm X-ray images of different individuals. Then the reconstruction result is regarded as a new specific coronary artery model, and conversely, the two models are fused to obtain a more general coronary artery model. Finally, By adding the updated results into the coronary artery model library, this method can continuously enhance the applicability and integrity of the model base by recursion, thus providing objective guidance and reference for clinical treatment or research. In addition, the paper also introduces the application of dynamic model in 3D reconstruction on matching and cardiac motion compensation, and makes a simulation experiment of single-arm X-ray imaging system using coronary artery model. The validity of the heart motion compensation algorithm is verified.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：TP391.7;R312

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