非人灵长类动物慢性肾病模型研究进展

发布时间：2018-03-05 02:21

本文选题：非人灵长类　切入点：慢性肾病模型　出处：《动物医学进展》2017年05期 　论文类型：期刊论文

【摘要】：慢性肾病(Chronic kindey disease,CKD)作为高发病率、低防治率的常见疾病之一,目前尚无非人灵长类动物在CKD模型中应用的进展报告。建立CKD模型的非人灵长类动物主要是猕猴属中恒河猴、食蟹猴和豚尾猴3种。从造模方式看,主要采用的方法有诱导性模型和自发性模型两种。诱导型造模可分为药物诱导、免疫诱导、重金属化合物诱导、辐射损伤、生物诱导等不同方法。从肾脏病理改变看,有以肾小球病理改变为主,如猪尾猴疟原虫、牛丙种球蛋白等诱导者;有以肾小管病理改变为主,如氯化镉、顺铂等诱导者;有兼顾肾小球和肾小管损伤,如猴免疫缺陷病毒(SHIV)诱导者。为利用非人灵长类动物进行CKD相关研究提供了方法学汇总,具有一定参考价值。
[Abstract]:As one of the common diseases with high incidence and low prevention rate, there is no progress report on the application of non-human primates in CKD model. The non-human primates that establish CKD model are mainly middle rhesus monkeys of rhesus genus. There are three kinds of animal models in crab-eating monkey and dolphin tail monkey. The main methods are inductive model and spontaneous model. The induced model can be divided into drug induction, immune induction, heavy metal compound induction, radiation damage, and so on, which can be divided into three types: drug induction, immune induction, heavy metal compound induction and radiation damage. According to the pathological changes of kidney, there were mainly glomerular pathological changes, such as Plasmodium falciparum, Bovine Gammaglobulin and so on, others were mainly renal tubule pathological changes, such as cadmium chloride, cisplatin and so on. There are both glomerular and tubular injuries, such as simian immunodeficiency virus (siRNA) -induced human immunodeficiency virus (SHIV), which provides a methodology summary for the use of non-human primates for CKD related research, and has a certain reference value.
【作者单位】：西南医科大学中西医结合研究中心;西南医科大学人体解剖学教研室;
【基金】：宜宾县院合作项目(2011JTD0014)
【分类号】：R-332;R692

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