静宁颗粒对注意力缺陷多动障碍模型大鼠注意定势转移能力的影响

发布时间：2018-03-05 15:23

本文选题：静宁颗粒　切入点：注意力缺陷多动障碍　出处：《北京中医药大学学报》2017年06期 　论文类型：期刊论文

【摘要】：目的观察注意力缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)模型大鼠注意定势转移能力变化及静宁颗粒对其的影响。方法采用自发性高血压大鼠(spontaneously hypertensive rats,SHR)作为ADHD的模型大鼠,分别给予静宁颗粒(20.25、10.125、5.062 5 g/kg)、盐酸哌甲酯缓释片(利他林6.75 mg/kg)和小儿黄龙颗粒(0.937 5 g/kg),连续给药17 d进行治疗。以大鼠注意定势转移任务(Attentional set-shifting,AST)中错误次数、挖掘次数、错误率等行为学指标,评价药物的药效。结果与正常对照组比较,模型大鼠在简单辨别(SD)阶段、复杂辨别(CD)阶段、内维度转换(IDS)阶段、逆反学习(RL)阶段、外维度转换(EDS)阶段错误次数、错误率、挖掘次数均增加;与模型组比较,静宁颗粒连续给药17 d后,各剂量可降低模型大鼠错误次数、错误率、挖掘次数,改善ADHD模型大鼠注意定势转移缺陷。结论 ADHD模型大鼠具有注意定势转移缺陷,静宁颗粒可有效改善ADHD模型大鼠的注意定势转移能力。
[Abstract]:Objective to observe the change of attention setting transfer ability of attention deficit hyperactivity disorder (ADHD) rats and the effect of Jingning granule on it. Methods spontaneous hypertensive rats were used as model rats of ADHD. Jingning granules were given 20. 25 渭 g / kg 10. 125n 5. 062 5 g / kg, 6. 75 mg / kg Ritalin hydrochloride sustained release tablets and 0. 937 5 g / kg Huanglong granule for 17 days. The number of errors and the number of excavations in the attention set transfer task of rats were observed, and the number of times of excavating the drug was compared with that of Ritalin hydrochloride sustained release tablet (Ritalin 6. 75 mg / kg) and Huanglong granule of children (0. 937 5 g / kg) for 17 days. Results compared with the normal control group, the model rats were in the simple discrimination stage, the complex discrimination stage, the internal dimension conversion stage and the inverse learning stage. The number of errors, the error rate and the times of mining were increased in the outer dimension conversion EDS stage, and compared with the model group, after 17 days of continuous administration of Jingning granule, the number of errors, the error rate and the times of mining were decreased in each dose of Jingning granule. Conclusion ADHD model rats have attentional homeostasis defect and Jingning granule can effectively improve the attention set transfer ability of ADHD model rats.
【作者单位】：北京中医药大学中药学院;
【基金】：国家科技重大专项(No.2014ZX09304306-002)~~
【分类号】：R285.5;R-332

【相似文献】