TNFAIP1调控机制及其在疾病发生中的作用
发布时间:2018-03-06 18:03
本文选题:TNFAIP 切入点:分子结构 出处:《重庆医学》2017年12期 论文类型:期刊论文
【摘要】:正人TNF-α诱导蛋白1(TNFAIP1)又名B12和hBACURD2,是第一个被鉴定出的TNF-α诱导产生的蛋白,属于hBACURD家族和PDIP1家族成员。人TNFAIP1基因首次(1992年)在TNF-α刺激、环己酰亚胺(Cycloheximide)处理的人脐静脉内皮细胞(HUVE)中克隆得到。人TNFAIP1基因是高度保守的单拷贝基因,定位于人染色体17q22-q23,而小鼠TNFAIP1基因采用YAC载体在鼠11号染色体克隆得到。近
[Abstract]:Is human TNF- alpha induced protein 1 (TNFAIP1) also known as B12 and hBACURD2, is the first identified TNF- alpha induced protein, are members of the hBACURD family and PDIP1 family. TNFAIP1 gene for the first time (1992) in the stimulation of TNF- alpha, cycloheximide (Cycloheximide) treated human umbilical vein endothelial cells (HUVE) was cloned. TNFAIP1 gene is a single copy gene, located on human chromosome 17q22-q23 and YAC vectors in mouse chromosome 11 by cloning of mouse TNFAIP1 gene.
【作者单位】: 广东医科大学东莞科研中心/广东省医学分子诊断重点实验室;
【基金】:国家自然科学基金资助项目(81500007,81272434)
【分类号】:R363
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本文编号:1575896
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