突触后致密区蛋白-95与突触可塑性研究进展

发布时间：2018-03-08 17:29

本文选题：突触后致密区蛋白(PSD)-　切入点：突触可塑性　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：正突触是神经元之间的连接部位,生物信号通过突触前膜经突触传递到突触后膜。突触数量和功效的改变可引起突触可塑性的改变~(〔1〕)。突触可塑性是学习和记忆的神经基础。突触后致密区(PSD)是突触后信号转导和整合的结构基础,而PSD-95是新近在谷氨酸能突触的PSD中发现的一种特殊蛋白质~(〔2〕),能够整合N-甲基-D-天冬氨酸(NMDA)受体信号。该蛋白与突触可塑性密切相关。本文就PSD-95与突触可塑性研究
[Abstract]:Positive synapses are the junction between neurons. Biological signals are transmitted through the presynaptic membrane to the postsynaptic membrane. Changes in the number and efficacy of synapses can cause changes in synaptic plasticity. Synaptic plasticity is the neural basis for learning and memory. PSDs in the postsynaptic compact region are synapses. The structural basis of post-signal transduction and integration, PSD-95 is a special protein recently found in glutamate synaptic PSD, which can integrate the signal of N- methyl-Daspartic acid receptor. This protein is closely related to synaptic plasticity. This paper deals with the relationship between PSD-95 and synaptic plasticity.
【作者单位】：呼和浩特市第一医院;内蒙古医科大学;
【基金】：2012年国家自然科学基金项目(No.81260650) 2012年呼和浩特市重大科技专项基金(No.201215103000036)
【分类号】：R338

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