中药穴位敷贴对实验性乳腺增生模型大鼠雌、孕激素受体表达的影响

发布时间：2018-03-09 01:16

本文选题：乳腺增生　切入点：中药穴位敷贴　出处：《广州中医药大学学报》2016年06期 　论文类型：期刊论文

【摘要】：【目的】探讨中药穴位敷贴疗法对实验性乳腺增生模型大鼠的作用机制。【方法】将30只SD(远交群)大鼠随机分为正常组、模型组、穴位敷贴组,每组10只。采用雌激素诱导法复制大鼠实验性乳腺增生模型,以中药穴位敷贴治疗。采用免疫组织化学染色方法,观察各组大鼠乳腺组织细胞中雌激素受体(ER)、孕激素受体(PR)的分布或含量。【结果】与正常组比较,模型组ER、PR表达水平显著升高(P0.01)。与模型组比较,穴位敷贴组ER、PR表达水平显著降低(P0.01)。【结论】中药穴位敷贴疗法可能通过下调乳腺组织ER、PR表达,从而起到抑制乳腺增生的作用。
[Abstract]:[objective] to investigate the mechanism of acupoint application of traditional Chinese medicine on experimental mammary hyperplasia in rats. [methods] Thirty SD rats were randomly divided into normal group, model group and acupoint application group. The experimental mammary hyperplasia model was induced by estrogen in 10 rats in each group. The experimental mammary gland hyperplasia model was treated with acupoint application of traditional Chinese medicine. To observe the distribution or content of estrogen receptor ERA and progesterone receptor PRA in breast tissue cells of rats in each group. [results] compared with the normal group, the expression of ERP PR in the model group was significantly higher than that in the normal group, and compared with the model group, the expression level of ERP PR in the model group was significantly higher than that in the model group. The expression level of ERP PR in acupoint application group decreased significantly (P 0.01). [conclusion] traditional Chinese medicine acupoint application therapy may inhibit the proliferation of mammary gland by down-regulating the expression of ERP PR in mammary gland tissue.
【作者单位】：广州中医药大学针灸康复临床医学院;广州中医药大学第一临床医学院;
【基金】：广州中医药大学青年教师科研创新基金项目(编号:06c026)
【分类号】：R-332;R245

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