脊髓挫裂伤模型大鼠造模方式的选择:网状Meta分析

发布时间：2018-03-09 16:34

本文选题：脊髓损伤　切入点：模型　出处：《中国组织工程研究》2016年18期 　论文类型：期刊论文

【摘要】：背景:在进行脊髓损伤相关动物实验研究时,均将致伤方式与临床脊髓损伤的相似性作为造模方式选择的一个重要参考指标。目的:比较使用精密打击器、自制Allen’s打击器、脊髓压迫法及钳夹法进行大鼠脊髓损伤造模的异同,为脊髓损伤大鼠模型的造模方式选择提供新的依据。方法:检索Pub Med、中国知网、万方、维普数据库,检索时间截至2015年6月20日,纳入符合条件的文献,使用ADDIS软件进行分析。结果与结论:26项研究符合纳入标准,包含599只大鼠,对纳入研究进行分析后,各造模方式均可有效造模,最优造模方式依次为:精密打击器钳夹法自制Allen’s打击器压迫法;最低死亡率依次为:精密打击器自制Allen’s打击器钳夹法。从对功能影响和死亡率角度来说,使用精密打击器为优造模方式,而使用自制Allen’s打击器为最为经济,钳夹法可在两者之前取得平衡。
[Abstract]:Background: in the experimental study of spinal cord injury related animals, the similarity between the injury mode and clinical spinal cord injury is regarded as an important reference index for the selection of the model. Objective: to compare the use of precision batter and self-made Allen's batter. Spinal cord compression method and clamp method were used to make spinal cord injury model in rats, which provided a new basis for the model selection of spinal cord injury rat model. The retrieval time as of June 20th 2015 was analyzed by using ADDIS software. Results and conclusions: 26 studies met the inclusion criteria, including 599 rats. Each model making method can be used effectively. The optimal model making method is: precision hammer clamp method self-made Allen's punch press method; The lowest mortality rate is as follows: precision batter self-made Allen's hammer clamp method. From the point of view of function and mortality, the use of precision hammer is the best mode of modeling, and the use of home-made Allen's batter is the most economical. The clamp method can strike a balance between the two.
【作者单位】：广西中医药大学研究生院;广西中医药大学第一附属医院康复医学科;
【基金】：国家自然科学基金地区基金项目(81460746):基于HIF-1α/VEGF信号通路探讨电针刺激对脊髓损伤神经再生微环境调控机制研究~~
【分类号】：R651.2;R-332

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