赛拉嗪联合右美托咪定麻醉建立犬脊髓损伤模型的效果观察

发布时间：2018-03-10 07:06

本文选题：赛拉嗪　切入点：右美托咪定　出处：《西安交通大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的观察应用赛拉嗪联合右美托咪对建立比格犬脊髓损伤模型的麻醉效果。方法用随机数字表法将30只纯种雌性比格犬分为3组(n=10):赛拉嗪组(S组)、右美托咪定组(D组)、赛拉嗪+右美托咪定组(S+D组)。基础麻醉后,S组首次肌肉注射赛拉嗪0.08mL/kg,术中间断追加首次剂量1/3赛拉嗪维持麻醉,D组持续静脉注射右美托咪定2μg/(kg·h),S+D组持续静脉注射右美托咪定0.5μg/(kg·h),每隔30min肌肉注射赛拉嗪0.02mL/kg。观察记录切皮(T1)、手术开始后30min(T2)、手术结束前30min(T3)、手术结束(T4)4个时间点的心率(HR)、呼吸频率(RR)、Ramsay评分、前肢痉挛指数(SI),并记录麻醉药物使用量。结果 S+D组赛拉嗪、右美托咪定用量比S组和D组分别减少1/2和1/4(P0.01),而呼吸频率和心率无明显改变,镇静效果优于S组,术中前肢未出现肌张力明显增高情况。结论赛拉嗪联合右美托咪定在用于建立比格犬脊髓损伤模型中,具有呼吸抑制轻、镇静效果好和减少麻醉药物用量等优点。
[Abstract]:Objective to observe the anesthetic effect of seprazine combined with dexmetomide on the establishment of Spinal Cord injury Model in Beagle Dogs. Methods Thirty purebred female Beagle dogs were randomly divided into 3 groups: group S, group S, and group D, respectively. After basic anesthesia, the first intramuscular injection of Syrazine 0.08 mL / kg was performed in group S, and the initial dose of 1/3 mg / kg was continuously added during the operation. Group D received continuous intravenous injection of dexmetomidine 2 渭 g / kg 路hm-1 / kg / kg after basic anesthesia. Group D was given continuous intravenous injection of dexmetidine 2 渭 g / kg / kg / h after basic anesthesia, followed by continuous intravenous injection of 2 渭 g / kg / kg of dexamethiadine. Dexmetomidine 0.5 渭 g / kg 路hm-1 / h was injected intramuscularly every 30 minutes, and Secrazine 0.02 mL / kg / kg was injected intramuscularly. The heart rate (HRR), respiratory rate (RRN) Ramsay score were measured at 30 min after operation, 30 min after operation, 30 min after operation, 30 min before operation and 30 min after operation. Results compared with group S and group D, the dosage of ceprazine and dexmetidine decreased by 1/2 and 1 / 4, respectively, while the respiratory rate and heart rate did not change significantly, and the sedative effect was better than that of group S. Conclusion Syrazine combined with dexmetidine in the establishment of Spinal Cord injury model of Beagle dog has the advantages of mild respiratory inhibition, good sedative effect and reducing the amount of anesthetic.
【作者单位】：天津医科大学研究生院;武警后勤学院附属医院麻醉科;恩施州中心医院麻醉科;
【基金】：武警后勤学院基础研究项目(No.WHJ2014016)~~
【分类号】：R614;R-332

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