自体半腱肌腱重建距跟骨间韧带动物模型

发布时间：2018-03-16 15:40

本文选题：兔　切入点：距下关节　出处：《中国运动医学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的:利用自体半腱肌腱移植建立距跟骨间韧带重建的动物模型。方法:将72只新西兰白兔随机分为重建组、切断组和对照组。分别于4周、8周、16周、32周取材,对3个实验组术前术后体重变化,重建韧带的影像学、组织学和生物力学结果以及术后距下关节的活动范围进行评估。结果:术后8周以后实验动物体重变化出现差别,韧带切断组较重建组体重多增加0.32 kg(P=0.04);影像学、组织学和生物力学均支持移植韧带成活,生物力学研究发现韧带牵拉时出现2个张力屈服点;术后3组距下关节冠状面(P0.05)和水平面(P0.001)活动度差异有统计学意义。结论:利用自体半腱肌腱移植重建距跟骨间韧带可有效恢复距下关节的解剖和功能。移植韧带经过坏死、塑形改建、成熟的过程与骨道形成末端结构愈合。对于研究距下关节稳定性、韧带断裂后关节的继发性改变、韧带移植重建的转归提供了良好的动物模型材料。
[Abstract]:Objective: to establish an animal model of reconstruction of intercalcaneal ligament with semitendinosus tendon autograft. Methods: 72 New Zealand white rabbits were randomly divided into reconstruction group, transection group and control group. The changes of body weight before and after operation, the imaging, histological and biomechanical results of the reconstructed ligaments and the range of movement of the subtalar joint in the three experimental groups were evaluated. Results: after 8 weeks of operation, there were differences in the weight changes of the experimental animals. The weight of ligamentotomy group was 0.32 kg / kg, and the survival of graft ligament was supported by imaging, histology and biomechanics. The biomechanical study showed that there were two tension yield points in ligamentum ligamentum. There were statistically significant differences in the range of motion between the three groups (P 0.05) and P 0.001). Conclusion: reconstruction of the intercalcaneal ligament with autogenous semitendinosus tendon can effectively restore the anatomy and function of the subtalar joint. It provides a good animal model material for studying the stability of subtalar joint, the secondary change of joint after ligament rupture and the outcome of ligament graft reconstruction.
【作者单位】：北京大学国际医院骨科部;北京大学第三医院运动医学研究所;
【分类号】：R687.2;R-332

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