免疫应答中基因表达的转录延伸调控

发布时间：2018-03-21 11:38

  本文选题：基因表达　切入点：转录延伸　出处：《中国免疫学杂志》2017年08期 　论文类型：期刊论文

【摘要】：基因转录是一个有序的多步骤过程,包括转录起始前、转录起始和转录延伸等几个阶段。长期以来,转录起始前及转录起始阶段调控一直被认为是基因转录的关键限速步骤。然而,近年来利用全基因组深度测序等新技术对转录过程的深入研究,发现转录起始后的转录延伸阶段也是许多基因表达调控的关键步骤,并且这种调控机制在从果蝇到哺乳动物的不同物种之间高度保守。本文综述了NELF、DSIF和P-TEFb等主要转录延伸调控因子调控RNA聚合酶Ⅱ转录暂停和高效转录延伸最新分子机制,并讨论了转录延伸调控在癌症、炎症以及病毒感染等疾病发生中的作用。
[Abstract]:Gene transcription is an orderly multistep process that includes several stages, including pre-transcriptional initiation, transcriptional initiation and transcriptional extension. The regulation of pretranscriptional and transcriptional initiation stages has been considered to be a key rate-limiting step in gene transcription. However, in recent years, novel techniques such as full-genome deep sequencing have been used to further study the transcription process. It has been found that the transcriptional extension after transcription initiation is also a key step in the regulation of many genes expression. This regulation mechanism is highly conserved in different species from Drosophila to mammal. This paper reviews the latest molecular mechanisms of RNA polymerase 鈪，

本文编号：1643686