实验性高脂血症动物模型比较分析

发布时间：2018-03-23 06:07

本文选题：高脂血症　切入点：动物模型　出处：《中国中药杂志》2016年20期 　论文类型：期刊论文

【摘要】：高脂血症是诱发脂肪肝、动脉粥样硬化、高血黏、冠心病及脑卒中等病的重要危险因素。近年来,随着高脂血症的发病率逐年升高和低龄化趋势增加及其心脑血管并发症等日益明显。高脂血症的病因病机、预防治疗及降脂新药的研究开发成为了医药学界的研究热点。为了有效寻找高脂血症的发病机制和防治措施及中药治疗药物,选择理想的高脂血症动物模型复制方法、制备适合能展示中药特色优势的动物模型尤为重要。然而高脂血症动物模型的复制成功与否是实验性高脂血症研究的关键之一。理想的高脂血症动物模型应该是与人类疾病接近,在高脂血症发病过程中的生理、生化反应也尽可能与人类相一致,模型复制可重复,且试验操作简单、实验成本相对较低、易于推广;模型复制成功与否直接影响整个实验过程的准确性和结果的可靠性。该文就实验性高脂血症动物模型复制方法的研究进行比较分析,为降血脂中药新药研发者合理有效的选择高脂血症动物模型复制方法提供参考和依据。
[Abstract]:Hyperlipidemia is an important risk factor for fatty liver, atherosclerosis, hyperviscosity, coronary heart disease and stroke. As the incidence of hyperlipidemia increases year by year and the trend of younger age increases and the cardiovascular and cerebrovascular complications become more and more obvious, the etiology and pathogenesis of hyperlipidemia, In order to find out the pathogenesis and preventive measures of hyperlipidemia and traditional Chinese medicine treatment drugs, the ideal animal model of hyperlipidemia should be selected. It is particularly important to prepare animal models suitable for demonstrating the advantages of traditional Chinese medicine. However, whether the animal model of hyperlipidemia is successful or not is one of the keys to the study of experimental hyperlipidemia. The ideal animal model of hyperlipidemia should be. Close to human disease, The physiological and biochemical reactions in the pathogenesis of hyperlipidemia were as consistent as possible with those of human beings. The model replication was repeatable, and the experiment was simple, the cost of experiment was relatively low, and the experiment was easy to be popularized. The success of model replication directly affects the accuracy of the whole experiment and the reliability of the results. This paper makes a comparative analysis on the methods of experimental hyperlipidemia animal model replication. To provide reference and basis for the rational and effective selection of animal model of hyperlipidemia for the research and development of new Chinese medicine for lowering blood lipids.
【作者单位】：江西中医药大学;浙江中医药大学;温州医科大学;浙江工业大学;
【基金】：国家“重大新药创制”科技重大专项(2014ZX09301307-013,2011ZX09102-011-07) 国家自然科学基金项目(81560637) 江西省卫生厅中医药管理局科研基金项目(2014A041) 江西省教育厅科研项目(GJJ150862)
【分类号】：R-332;R259

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