游泳对高脂膳食诱导肥胖和肥胖抵抗模型大鼠的作用

发布时间：2018-03-24 03:09

本文选题：肥胖症　切入点：瘦素　出处：《中国组织工程研究》2016年27期

【摘要】：背景:高脂膳食诱导的肥胖动物是研究人类肥胖的首选模型,瘦素及其受体的表达在高脂膳食诱导的肥胖和肥胖抵抗中发挥重要作用,但其确切机制和游泳对它的作用还不清楚。目的:在肥胖和肥胖抵抗的基础上,探讨7周游泳运动对高脂膳食大鼠血清瘦素及下丘脑瘦素受体表达的影响。方法:60只SD大鼠高脂饲料喂养8周,根据体质量筛选出肥胖和肥胖抵抗大鼠。取14只肥胖大鼠等分为肥胖组和肥胖运动组,取14只肥胖抵抗大鼠等分为肥胖抵抗组和肥胖抵抗运动组。各组大鼠继续高脂膳食喂养。肥胖运动组和肥胖抵抗运动组大鼠同时进行连续7周的自由游泳运动训练。结果与结论:与肥胖组相比,肥胖运动组大鼠体质量、脂肪量、脂体比、血清瘦素浓度显著降低,下丘脑瘦素受体的基因表达水平显著升高;而与肥胖抵抗组相比,肥胖抵抗运动组大鼠上述指标无明显变化。说明游泳能够增加肥胖大鼠机体的能量消耗,加快脂肪分解,降低血液中瘦素浓度,有效增加下丘脑瘦素受体的基因表达水平,从而缓解瘦素抵抗,改善机体代谢水平。
[Abstract]:Background: obese animals induced by high fat diet are the first choice to study human obesity. The expression of leptin and its receptor plays an important role in obesity and obesity resistance induced by high fat diet. But the exact mechanisms and effects of swimming on it are unclear. Objective: based on obesity and obesity resistance, To investigate the effects of swimming for 7 weeks on the expression of leptin in serum and leptin receptor in hypothalamus of rats with high fat diet. Methods Sixty SD rats were fed with high fat diet for 8 weeks. Obesity and obesity resistant rats were selected according to body mass. Fourteen obese rats were divided into obese group and obese exercise group. 14 obese resistant rats were divided into obesity resistance group and obesity resistance exercise group. Rats in each group were fed with high fat diet. Rats in obese exercise group and obesity resistance exercise group were trained in free swimming for 7 weeks at the same time. Results and conclusions: compared with the obese group, In obese exercise group, the body weight, fat content, fat body ratio, serum leptin concentration and the expression level of leptin receptor gene in hypothalamus were significantly decreased, but compared with those in obese resistance group, the expression of leptin receptor gene in hypothalamus was significantly increased in obese exercise group. The results showed that swimming could increase the energy consumption, accelerate fat decomposition, decrease the concentration of leptin in blood and increase the gene expression level of leptin receptor in hypothalamus of obese rats, which indicated that swimming could increase the energy consumption, accelerate fat decomposition, decrease the concentration of leptin in blood, and increase the expression of leptin receptor gene in hypothalamus. So as to alleviate leptin resistance, improve the metabolism level of the body.
【作者单位】：沈阳体育学院运动人体科学学院;国家体育总局秦皇岛训练基地;贵州省体育科学研究所;
【基金】：辽宁省高等学校优秀人才支持项目(WR2013015) 沈阳体育学院重点学科建设项目(XKFX1511)~~
【分类号】：R589.2;R-332

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