结核分枝杆菌免疫逃避机制研究进展

发布时间：2018-03-27 12:41

本文选题：结核分枝杆菌　切入点：逃逸机制　出处：《中国人兽共患病学报》2017年08期

【摘要】：结核病(Tuberculosis TB)主要由结核分枝杆菌(Mycobacterium tuberculosis,Mtb)感染引起,结核分枝杆菌在机体中长期存在与其逃避机体免疫杀伤机制密切相关。已发现的结核分枝杆菌免疫逃避机制包括阻止巨噬细胞吞噬溶酶体的成熟及酸化,抑制氧化应激反应,抑制细胞凋亡及自噬等。结核分枝杆菌逃避宿主免疫杀伤的机制错综复杂,目前尚未完全明了,本文就结核分枝杆菌免疫逃避机制做一综述,为其深入研究提供参考。
[Abstract]:Tuberculosis tuberculosis (TB) is mainly caused by Mycobacterium tuberculosisus Mtb (Mycobacterium tuberculosisus Mtb) infection. Mycobacterium tuberculosis has long existed in the body and is closely related to its immune mechanism. The mechanism of immune evasion of Mycobacterium tuberculosis includes preventing macrophages from phagocytic lysosome maturation and acidification and inhibiting oxidative stress response. Inhibition of apoptosis and autophagy. The mechanism of mycobacterium tuberculosis escaping from host immunity and killing is complicated and not fully understood. This paper reviews the mechanism of immune evasion of Mycobacterium tuberculosis and provides a reference for its further study.
【作者单位】：同济大学附属上海市肺科医院检验科;
【基金】：国家自然科学基金(No.81371775)~~
【分类号】：R378.911

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