食管康对反流性食管炎模型大鼠SOD、GSH影响的实验研究

发布时间：2018-03-30 05:03

本文选题：反流性食管炎　切入点：食管康　出处：《时珍国医国药》2016年08期

【摘要】：目的研究反流性食管炎(RE)基本病机及食管康治疗RE的作用机理。方法将60只雄性Wistar大鼠随机分成假手术组、模型组、食管康组、中成药组(三九胃泰颗粒)、西药组(兰索拉唑+莫沙必利)。采用"4.2mm幽门夹+胃底2/3结扎术"制备反流性食管炎动物模型。相应实验处理后,观察食管下段黏膜病理组织学变化及大鼠食管黏膜组织SOD和GSH含量的表达情况。结果与假手术组相比,模型组大鼠体重明显减轻(P0.05),食管黏膜肉眼及镜下病理改善明显,评分增高(P0.05);食管黏膜组织SOD、GSH含量显著降低(P0.05);与模型组及中成药组相比,食管康组死亡率明显降低(P0.05),肉眼及病理评分显著降低(P0.05);与西药组相比,大鼠食管黏膜SOD、GSH含量明显改善(P0.05)。结论食管康能够明显提高RE大鼠食管黏膜SOD、GSH含量,从而促进食管黏膜损伤修复,改善RE症状。
[Abstract]:Objective to study the basic pathogenesis of reflux esophagitis and the mechanism of the treatment of RE. Methods 60 male Wistar rats were randomly divided into three groups: sham operation group, model group and yukang group. The Chinese patent medicine group (Sanjiuweitai granule group) and the western medicine group (lansoprazole mosapride group) were used to establish the animal model of reflux esophagitis by "4.2mm pyloric entrapment with gastric fundus 2 / 3 ligation". To observe the histopathological changes of the lower esophageal mucosa and the expression of SOD and GSH in the esophageal mucosa of rats. Results compared with the sham operation group, the weight of the model group was significantly lower than that of the sham-operated group, and the pathological changes of the esophageal mucosa were obviously improved by naked eye and microscope. Compared with the model group and the traditional Chinese medicine group, the mortality rate of the esophagus group was significantly lower than that of the model group and the traditional Chinese medicine group, and the naked eye and pathological score were significantly lower than that of the western medicine group, and that of the western medicine group was significantly lower than that of the western medicine group, and that of the esophageal mucosal tissue was significantly lower than that of the model group and the traditional Chinese medicine group. Conclusion the content of SODN GSH in esophageal mucosa of RE rats can be significantly increased, thereby promoting the repair of esophageal mucosal injury and improving the symptoms of RE.
【作者单位】：天津中医药大学;天津中医药大学管理学院;
【基金】：天津市科委科技支撑项目计划(No.12ZCZDSY01500)
【分类号】：R285.5;R-332

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