艾叶挥发油对耳肿胀急性炎症模型小鼠的抗炎作用研究

发布时间：2018-04-01 21:25

本文选题：艾叶挥发油　切入点：耳肿胀　出处：《浙江中医杂志》2016年04期

【摘要】：目的:探讨艾叶油对小鼠耳肿胀急性炎症模型的抗炎作用。方法:采用二甲苯致小鼠耳肿胀急性炎症模型,比较致炎剂保留时间与耳壳肿胀程度的关系,观察二甲苯滴耳致炎后不同时间小鼠耳壳肿胀度的变化,并观察艾叶挥发油在二甲苯致炎最佳时间的抗炎作用研究。结果:在二甲苯作用15min~180min范围时,小鼠耳壳肿胀程度与正常对照组比较有显著差异(P0.05),二甲苯作用时间40min肿胀度达到最大值(P0.01);艾叶挥发油低剂量、高剂量组对二甲苯致炎的小鼠耳肿胀均有显著的抑制作用(P0.01),低剂量与阳性对照组比较有显著性差异(P0.05)。结论:采用二甲苯致炎模型进行实验研究时,二甲苯的最佳作用时间为40min左右;艾叶挥发油低剂量组对二甲苯致炎的小鼠耳肿胀的抑制作用更为明显。
[Abstract]:Objective: to study the anti-inflammatory effect of Artemisia argyi oil on acute inflammatory model of ear swelling in mice. Methods: to compare the relationship between the retention time of artemisia and the degree of ear shell swelling in mice induced by xylene. To observe the changes of ear shell swelling in mice at different time after ear inflammation induced by dimethylbenzene, and to observe the anti-inflammatory effect of the essential oil of Artemisia argyi leaf on the best time of xylene induced inflammation. Results: when xylene acted on 15min~180min, The degree of ear shell swelling in mice was significantly different from that in normal control group (P 0.05), the 40min swelling degree of xylene reached the maximum value (P 0.01), and the low dose of essential oil of Artemisia argyi leaves. In the high dose group, the ear swelling of mice induced by xylene was significantly inhibited, and there was a significant difference between the low dose group and the positive control group (P 0.05). Conclusion: when the model of xylene induced inflammation was used in the experimental study, there was a significant difference between the low dose group and the positive control group. The best time of action of xylene was about 40min, and the inhibition of ear swelling in mice induced by xylene was more obvious in the low dosage group of essential oil of Artemisia argyi.
【作者单位】：浙江省立同德医院;
【分类号】：R285.5;R-332

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