跑台运动对高龄大鼠运动机能的改善作用

发布时间：2018-04-04 05:27

本文选题：衰老　切入点：运动机能　出处：《中国实验动物学报》2017年01期

【摘要】：目的探讨大鼠运动机能随增龄的变化规律,以及运动对高龄大鼠运动机能的改善作用。方法对26月龄、8月龄和2月龄SD大鼠进行为期2周的中等强度跑台运动干预,测定大鼠运动前后前肢拉力、耐力、躯体向上活动能力及极限速度4个机能指标,进行对比分析。结果 126月龄大鼠组的前肢拉力、耐力、躯体向上活动能力、极限速度均显著低于8月龄组和2月龄组,且后3个指标呈现增龄性下降;226月龄和8月龄组的前肢拉力运动后高于运动前,8月龄组和2月龄组的躯体向上活动能力运动后高于运动前;3运动干预前后4项指标的运动机能总评分进行比较,26月龄组运动后显著高于运动前。结论大鼠的前肢拉力、耐力、躯体向上活动能力及极限速度等4项运动机能指标呈增龄性下降,可作为大鼠运动机能的衰老指标。中等强度的跑台运动能显著改善高龄大鼠总运动机能的下降。
[Abstract]:Objective to investigate the changes of motor function with age and the effect of exercise on motor function in aged rats.Methods SD rats aged 26 months or 8 months and 2 months of age were treated with moderate intensity treadmill exercise for 2 weeks. The four functional indexes of forelimb tension, endurance, body upward movement ability and limit speed were measured before and after exercise, and the results were compared and analyzed.Results in the 126-month-old group, the forelimb tension, endurance, body upward activity and ultimate velocity were significantly lower than those in the 8-month-old and 2-month-old groups.And the last three indexes showed that the body movement ability of the forelimb in 226 months and 8 months groups was higher than that in the 8 month group and the 2 month old group after exercise, and was higher than that in the 4 fingers before and after the intervention of 3 months old exercise before and after the exercise, and the later 3 indexes were higher than those in the group of 8 months old before exercise and the group of 2 months of age.The total score of motor function in 26 months group was significantly higher than that before exercise.Conclusion the four indexes of motor function, such as pulling strength, endurance, upward movement ability and limit speed of the forelimb, are decreased in aging, which can be used as an aging index of motor function in rats.Moderate treadmill exercise can significantly improve the decline of total motor function in aged rats.
【作者单位】：暨南大学再生医学教育部重点实验室科技部;广东省国际科技合作基地(暨南大学);暨南大学发育与再生生物学系;
【基金】：科技部港澳台合作专项(2012DFH30060) 国家自然科学基金(30973158,81170324,81470433) 广东省教育厅国际合作平台项目(2012gjhz0003) 广东省自然科学基金重点项目(04105826,S2012020010895) 863计划(2007AA02Z105) 广东省科技厅国际合作平台项目(2009B050900007,2013B051000062) 广东省科技计划项目(2015B020211010)
【分类号】：R-33

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