异黄酮衍生物J39136对东莨菪碱致学习记忆障碍模型小鼠的影响

发布时间：2018-04-16 18:19

  本文选题：J + 阿尔茨海默病　； 参考：《中国新药杂志》2017年10期

【摘要】：目的:本文旨在初步探讨具有乙、丁酰胆碱酯酶抑制活性的异黄酮衍生物J39136对小鼠东莨菪碱导致的学习记忆障碍的影响,为该化合物后续研究提供实验依据。方法:采用Morris水迷宫、跳台和避暗3个行为学实验,评价J39136不同剂量对小鼠认知和记忆的作用。结果:化合物J39136各给药组均有减少小鼠在避暗试验中的错误次数的趋势;J39136各剂量组均可显著延长小鼠的跳台潜伏期,减少小鼠的跳台错误次数,缩短小鼠在Morris水迷宫实验中的游泳潜伏期,具有一定的剂量依赖性。结论:化合物J39136能够改善东莨菪碱致学习记忆障碍,值得进行深入开发。
[Abstract]:Aim: to investigate the effect of isoflavone derivative J39136, which has inhibitory activity of acetylcholinesterase, on learning and memory impairment induced by scopolamine in mice, and to provide experimental basis for further study of the compound.Methods: the effects of different doses of J39136 on cognition and memory of mice were evaluated by using Morris water maze, treadmill and dark avoidance experiments.Results: each dose group of compound J39136 had a tendency to reduce the number of errors in the dark avoidance test in mice. Each dose group of J39136 could significantly prolong the latency of jumping platform in mice and reduce the number of errors in jumping platform in mice.The swimming latency of mice in Morris water maze test was shortened in a dose-dependent manner.Conclusion: compound J 39136 can improve learning and memory impairment induced by scopolamine.
【作者单位】： 中国医学科学院北京协和医学院药物研究所;河北医科大学第四医院;
【基金】：国家“重大新药创制”科技重大专项资助项目(2014ZX09507003-002,2013ZX09402203,2013ZX09508104001002) 中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-007) 国际合作项目(2011DFR31240)
【分类号】：R285.5;R-332
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本文编号：1760060