可溶性环氧化物水解酶在疾病中的作用

发布时间：2018-04-21 07:11

本文选题：可溶性环氧化物水解酶 + 环氧二十碳三烯酸　；参考：《中国生物化学与分子生物学报》2017年02期

【摘要】：花生四烯酸经过细胞色素P450(cytochrome P450,CYP)表氧化酶途径生成环氧二十碳三烯酸(epoxy eicosatrienoic acid,EETs),具有扩张血管、降低血压、抗炎等多种生物学功能。在哺乳动物系统中的可溶性环氧化物水解酶(soluble epoxide hydrolase,s EH)具有α/β水解酶折叠结构,对环氧脂肪酸具有高度的选择性。s EH能够快速水解EETs,增加患心血管疾病的风险。目前,研究发现s EH抑制剂具有抑制s EH活性、提高EETs的含量的重要功能。在多种疾病动物模型中应用s EH抑制剂或s EH基因敲除,证实s EH在心肌肥厚、糖尿病、高血压和肾病等疾病中发挥重要的生理作用。因此,s EH已被作为疾病治疗的新靶点而进行研究。本文就s EH的分布、作用机制以及s EH与疾病的关系等方面进行了讨论。
[Abstract]:Arachidonic acid (Arachidonic acid) produces epoxy-eicosyltrienoic acid eicosatrienoic (EETsN) via the cytochrome P450(cytochrome P450 CYPase pathway. Arachidonic acid has many biological functions, such as dilating blood vessels, lowering blood pressure, anti-inflammatory and so on. Soluble epoxide hydrolase (EH) in mammalian system has the folding structure of 伪 / 尾 hydrolase, and has a high selectivity for epoxide fatty acids. S EH can hydrolyze EETs rapidly and increase the risk of cardiovascular disease. At present, it has been found that s EH inhibitors have the important function of inhibiting the activity of s EH and increasing the content of EETs. The use of s EH inhibitor or s EH gene knockout in animal models of various diseases has proved that s EH plays an important physiological role in myocardial hypertrophy, diabetes, hypertension and nephropathy. Therefore, EH has been studied as a new target for disease treatment. In this paper, the distribution, mechanism of action of s EH and the relationship between s EH and disease are discussed.
【作者单位】：内蒙古农业大学乳品生物技术与工程教育部重点实验室;内蒙古骆驼研究院;
【基金】：国家自然科学基金项目(No.31360397) 国际科技合作项目(No.2015DFR30680,ky201401002) 内蒙古重大专项资助~~
【分类号】：R363

【相似文献】