不同免疫组化法检测PHH3蛋白染色的比较

发布时间：2018-04-21 23:40

本文选题：PHH + 免疫组织化学　；参考：《临床与实验病理学杂志》2017年03期

【摘要】：正组蛋白H3是细胞核染色质的重要组成成分,也是核心组蛋白之一~([1-2])。PHH3是磷酸化的组蛋白H3,其只存在细胞有丝分裂期而不出现于分裂间期和凋亡细胞中,从而有利于有丝分裂细胞的计数~([1-4])。Ribalta等~([4])报道PHH3蛋白可以帮助脑膜瘤的肿瘤分级以及区分凋亡细胞;在皮肤的平滑肌肿瘤中简单计数核分裂细胞~([5]);Tsuta等~([6]_认为,PHH3同样可以在肺神经内分泌癌中计数核分裂细胞;除此之外,PHH3还可以预测星形细胞瘤患者的生存期~([7]),协助子宫内膜癌的病理分级等~([8])。因此采用免疫组化(immunohisto-
[Abstract]:Positive histone H3 is an important component of nuclear chromatin and one of the core histone ([1-2] n.PHH3 is phosphorylated histone H3, which exists only in mitotic phase and not in intermitotic and apoptotic cells. It is helpful for mitotic cell count ([1-4], Ribalta et al. [4]) to report that PHH3 protein can help the tumor grade of meningioma and differentiate apoptotic cells. Mitotic cells were counted in smooth muscle tumors of skin. [5] Tsuta et al. ([6]) it was suggested that PHH3 could also count mitotic cells in lung neuroendocrine carcinoma. In addition, PHH3 can also predict the survival time of astrocytoma patients ([7]), assist in the pathological grading of endometrial carcinoma ([8]). So immunohistochemical staining was used.
【作者单位】：南京中医药大学附属医院/江苏省中医院病理科;
【分类号】：R329.33

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