miRNA调控成肌分化的研究进展

发布时间：2018-04-22 07:37

  本文选题：成肌分化 + miRNA　； 参考：《中国生物工程杂志》2017年10期

【摘要】：成肌分化过程包括成肌细胞的增殖,然后分化为肌细胞,最后融合形成肌管;microRNA(miRNA)是一类在转录后水平调控基因表达的微小非编码RNA,它通过靶向靶基因mRNA的3'UTR,抑制其翻译或诱导其降解。已有研究表明,miRNA在成肌分化中起重要调控作用。根据表达方式的不同,分为肌肉特异表达的miRNA,有miR-1,miR-133,miR-206,miR-208,miR-499和miR-486;和非肌肉特异表达的miRNA,其中miR-27,miR-29,miR-128,miR-199a和miR-431在成肌分化过程中具有重要的调控功能。另外,阐述了几个与miRNA相互作用从而调控成肌分化的lncRNA的功能。通过介绍两类miRNA的靶基因及调控机制,阐述了最新的研究进展。
[Abstract]:The process of myogenic differentiation involves the proliferation of myoblasts, which then differentiate into myocytes. Finally, myotube microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at post-transcriptional level. They inhibit their translation or induce their degradation by targeting the target gene mRNA's 3UTRs. It has been shown that miRNA plays an important role in myogenic differentiation. According to the different expression patterns, miRNAs were divided into muscle-specific miRNAs, including miR-1 miR-133nmiR-136 miR-206 miR-208miR-499 and miR-486, and non-muscle-specific miRNAs, in which miR-27 miR-29miR-29miR-128miR-199a and miR-431 had important regulatory functions in the process of myogenic differentiation. In addition, the functions of several lncRNA that interact with miRNA to regulate myogenic differentiation are described. Through introducing the target genes and regulatory mechanisms of two kinds of miRNA, the latest research progress was reviewed.
【作者单位】： 深圳大学生命与海洋科学学院;
【分类号】：R329.2
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本文编号：1786269