聚腺苷二磷酸-核糖聚合酶1与DNA双链断裂修复的相关性

发布时间：2018-04-22 20:49

本文选题：聚腺苷二磷酸-核糖聚合酶 + DNA双链断裂　；参考：《中国生物化学与分子生物学报》2016年06期

【摘要】：DNA双链断裂(double strand breaks,DSBs)是细胞最严重的DNA损伤形式。细胞通过同源重组(homologous recombination,HR)和非同源末端连接(non-homologous end joining,NHEJ)途径修复DNA双链断裂损伤。聚腺苷二磷酸核糖基化(poly(ADP-ribosyl)ation,PARylation)是蛋白质翻译后修饰过程,这个过程由聚腺苷二磷酸-核糖聚合酶家族(poly(ADP-ribose)polymerases,PARPs)催化完成。PARP1作为PARPs家族最重要的成员,其在DNA损伤应答方面发挥重要作用。研究显示,PARP1在DSBs修复过程中发挥关键作用,参与DSBs的早期应答反应及其具体修复途径,可依据KU蛋白的存在与否发挥不同的特定作用。本文较全面地综述了PARP1在DNA双链断裂修复方面的潜在作用,将为临床疾病的诊治提供新的思路。
[Abstract]:DNA double strand breaks (DSBs) is the most serious form of DNA damage in cells. DNA double-strand break damage was repaired by homologous recombination and non-homologous end joining (NHJI) pathway. Polyadenosine diphosphate ribosylation (PARylation) is a post-translational modification process of proteins, which is catalyzed by polyadenosine diphosphate ribosomal Polymerase family (Polyadenosine diphosphate-ribosomal Polymerase). As the most important member of the PARPs family, PARP1 plays an important role in DNA damage response. It has been shown that PARP1 plays a key role in the process of DSBs repair and participates in the early response of DSBs and its specific repair pathway, which can play different roles depending on the existence of Ku protein. This article reviews the potential role of PARP1 in the repair of DNA double strand breaks, which will provide a new idea for the diagnosis and treatment of clinical diseases.
【作者单位】：广东医科大学研究生学院;广东医科大学医学检验学院;广东医科大学生化教研室;
【基金】：国家自然科学基金项目(No.52402301-173-0) 广东省科技计划项目(No.2010B060900109) 广东省自然科学基金项目(No.S2012010008225)资助~~
【分类号】：R3416

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