Dicer调节生殖功能的研究进展

发布时间：2018-04-24 18:12

本文选题：miRNA + Dicer　；参考：《遗传》2016年07期

【摘要】：Dicer是微小非编码RNA生成的关键内切酶,介导微小RNA(micro RNA,mi RNA)和小干扰RNA(small interfering RNA,si RNA)的产生,通过RNA干扰(RNA interference,RNAi)途径实现转录或转录后水平基因调控,在调节细胞增殖、分化、凋亡等方面起重要作用。近年来Dicer基因在生殖领域的研究越来越受关注,最近的研究表明Dicer与男性生精细胞发育、精子形成及成熟、精子活力和形态生成、卵泡发育、排卵及黄体形成、性激素合成、输卵管功能、子宫内膜容受性等方面都有密切关系。繁衍后代需要精子和卵子的共同参与,Dicer可能通过影响精子和卵子的数量或者质量进而导致胚胎发育异常,因此理解Dicer在雄性与雌性生殖的重要调节作用对于理解生殖调节异常相关的疾病如无精子症、复发性流产等的发病机制具有重要的作用。本文对Dicer在雄性生殖道与雌性生殖中的关键作用进行了综述,旨在进一步从分子层面深入理解Dicer与生殖相关疾病的关系。
[Abstract]:Dicer is a key endonuclease for the production of small non-coding RNA. It mediates the production of microRNAs and small interfering RNA(small interfering RNAs (siRNAs). It regulates transcription or post-transcriptional level genes through the RNA interference RNA(small interference RNAi pathway, and regulates cell proliferation and differentiation. Apoptosis plays an important role. In recent years, more and more attention has been paid to the study of Dicer gene in the field of reproduction. Recent studies have shown that Dicer is associated with male spermatogenic cell development, sperm formation and maturation, sperm motility and morphogenesis, follicular development, ovulation and luteal formation, and sex hormone synthesis. Fallopian tube function, endometrial receptivity and other aspects are closely related. Reproduction requires the participation of sperm and eggs, and Dicer may affect the quantity or quality of sperm and eggs, leading to abnormal embryo development. Therefore, understanding the important regulatory role of Dicer in male and female reproduction plays an important role in understanding the pathogenesis of diseases related to abnormal reproductive regulation such as azoospermia and recurrent abortion. In this paper, the key roles of Dicer in male reproductive tract and female reproduction are reviewed in order to further understand the relationship between Dicer and reproductive diseases at the molecular level.
【作者单位】：成都中医药大学;四川大学华西第二医院四川大学-香港中文大学生殖医学联合实验室教育部出生缺陷与相关妇儿疾病重点实验室;
【基金】：国家重点基础研究计划(973计划)(编号:2012CB944903) 新世纪人才计划项目(编号:NCET-12-0382)资助~~
【分类号】：R339.2

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