环状RNA在慢性病发病中作用机制的研究进展

发布时间：2018-04-30 10:28

本文选题：环状RNA + 非编码RNA　；参考：《生理科学进展》2017年03期

【摘要】：环状RNA作为一种对基因表达进行精细调节的重要非编码RNA,不仅增加了非编码RNA介导的基因调控网络的复杂度,也加深了疾病发病机制研究的深度。虽然近年来环状RNA的功能研究有了长足的进步,确定了其作为ceRNA能够特异性吸附miRNA,解除相应miRNA对下游靶mRNA的抑制作用,此类研究也表明核外环状RNA介导的凋亡活化,增殖抑制和细胞与细胞间的交流在疾病发生发展过程中是至关重要的,但我们对环状RNA的了解还只是冰山一角,特别是病理状态下其作用的具体机制仍然需要我们不断探索。在此,本综述的主要目的是回顾目前关于环状RNA在心血管疾病、中枢神经系统疾病和癌症等慢性病领域的研究,探讨以上慢性病发病过程中环状RNA所起的作用以及展望未来环状RNA在疾病发病机制领域的研究。
[Abstract]:As an important noncoding RNAs for fine regulation of gene expression, cyclic RNA not only increases the complexity of gene regulatory network mediated by non-coding RNA, but also deepens the study of pathogenesis of disease. Although the functional study of cyclic RNA has made great progress in recent years, it has been confirmed that it can specifically adsorb miRNAs as ceRNA and remove the inhibitory effect of corresponding miRNA on downstream target mRNA. These studies have also demonstrated the activation of apoptosis mediated by extracellular cyclic RNA. The inhibition of proliferation and the communication between cells and cells are very important in the process of disease development, but our understanding of annular RNA is only the tip of the iceberg, especially the mechanism of its role in pathological state still needs to be explored. The main purpose of this review is to review current research on chronic diseases such as cardiovascular disease, central nervous system disease and cancer with annular RNA. To explore the role of annular RNA in the pathogenesis of chronic diseases and to look forward to the future study of annular RNA in the pathogenesis of the disease.
【作者单位】：宁波大学医学院预防医学系浙江省病理生理学技术研究重点实验室;
【基金】：浙江省社会发展研究项目(2016C33178) 宁波市社会攻关项目(2014C50051) 宁波大学科研创新基金项目(G16097) 宁波市环境有害因素致病机制及防制创新团队(2016C51001)资助课题
【分类号】：R363

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