转铁蛋白的结构功能和潜在临床应用价值

发布时间：2018-05-02 21:21

本文选题：转铁蛋白 + 转铁蛋白受体　；参考：《中国现代医学杂志》2017年26期

【摘要】：铁是维持细胞生长繁殖及代谢活动所必需的元素之一,机体内绝大多数游离铁是由转铁蛋白运输传递。转铁蛋白(Tf)是血浆中主要的结合并转运铁的β球蛋白,主要负责运载由胃肠道吸收的铁和由红细胞降解释放的铁。Tf的金属离子结合位点由2个酪氨酸、1个天冬氨酸和1个组氨酸残基构成。Tf除了转运铁外同时还具有许多生理生化功能,如抗菌活性、促细胞生长分化及细胞保护等,是一类多功能蛋白。此外,研究发现Tf还被发现可作为一种新型的药物主动靶向载体,在肿瘤靶向治疗领域中具有广阔的应用前景。该文从Tf的结构特性、多样性、生物学功能及临床应用等方面对Tf进行系统性综述。
[Abstract]:Iron is one of the essential elements to maintain cell growth, reproduction and metabolism. Most of the free iron in the body is transported by transferrin. Transferrin (TF) is the major binding and transporting 尾 globulin in plasma. The metal ion-binding sites mainly responsible for carrying iron absorbed by the gastrointestinal tract and iron. TF released by red blood cells are composed of two tyrosine, one aspartic acid and one histidine residue. Multiple physiological and biochemical functions, It is a kind of multifunctional protein, such as antibacterial activity, promoting cell growth and differentiation, cell protection and so on. In addition, TF has been found to be a novel active drug targeting carrier and has a broad application prospect in the field of tumor targeting therapy. This paper reviews the structure, diversity, biological function and clinical application of TF.
【作者单位】：中南大学湘雅医院;中南大学生命科学学院;
【基金】：国家自然科学基金(No:U1603126) 湖南省自然科学基金(No:2017JJ2334)
【分类号】：R3411

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