绿茶多酚对帕金森病模型小鼠运动和学习记忆功能的影响

发布时间：2018-05-03 11:40

本文选题：帕金森病 + 绿茶多酚　；参考：《中国临床药理学与治疗学》2016年08期

【摘要】：目的:探讨绿茶多酚(GTPs)对帕金森病(PD)模型小鼠运动和学习记忆功能的影响,为GTPs用于治疗PD提供实验基础。方法:取40只雄性C57BL小鼠(25~30 g),随机均分成正常组、模型组、GTPs低剂量组、GTPs高剂量组。模型组、GTPs低剂量组、GTPs高剂量组小鼠ip 1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)(30 mg/kg,qd)7 d造模后,分别进行Morris水迷宫、Rotor-rod实验、爬杆实验的检测。随后,GTPs低、高剂量组小鼠给予GTPs(ip,qd)14 d,模型组给予等容量生理盐水,并在给药完成的次日重复上述检测。结果:(1)与正常组相比,MPTP导致PD小鼠的Morris水迷宫测试的逃避潜伏期延长、爬杆实验的爬杆时间延长、Rotor-Rod实验的爬行持续时间缩短(n=10,均P0.05);(2)与模型组相比,GTPs可以缩短PD小鼠的水迷宫逃避潜伏期、爬杆实验的爬杆时间,并延长Rotor-Rod实验的爬行持续时间(n=10或5,均P0.05)。结论:GTPs对PD模型小鼠运动和学习记忆功能具有一定的改善作用。
[Abstract]:Aim: to investigate the effects of green tea polyphenols (GTPs) on the motor and learning and memory function of PD mice in order to provide experimental basis for the treatment of PD by GTPs. Methods: 40 male C57BL mice were randomly divided into normal group and model group. Morris water maze and rotor-rod test were performed in the model group with low dose of GTPs and high dose group of mice with high dose of IP 1-methyl-4-phenyl-1-dihydropyridine (MPTP) 30 mg / kg 路kg ~ (-1) 路d ~ (-1). Then the mice in the high dose group were given GTPsIQD for 14 days, and the model group were given the same volume of normal saline, and the above tests were repeated on the second day after the administration of GTPs. Results (1) compared with normal group, MPTP induced prolonged escape latency of Morris water maze test in PD mice. Compared with the model group, GTPs could shorten the escape latency of water labyrinth in PD mice. The creeping duration of Rotor-Rod test was prolonged to 10 or 5, respectively (P 0.05). Conclusion the function of motion and learning and memory in PD model mice was improved by the weight GTPs.
【作者单位】：皖南医学院细胞电生理研究室;皖南医学院启明星小组;
【基金】：省级大学生创新创业计划(AH201410368051) 皖南医学院大学生科研基金(WK2014S11) 国家自然科学基金(31271155)
【分类号】：R285.5;R-332

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