甘麦大枣汤对“怒”模型大鼠行为学特征的影响

发布时间：2018-05-07 15:53

本文选题：“怒”模型 + 甘麦大枣汤　；参考：《中华中医药杂志》2017年06期

【摘要】：目的:研究甘麦大枣汤对"怒"模型大鼠行为学特征的影响。方法:将40只Wistar雄性大鼠随机分成正常组、模型组、甘麦大枣汤组和香芍颗粒组,每组10只。除正常组外,其余各组以社会隔离与居住入侵方法进行"怒"模型大鼠复制。28d完成造模后,各组开始给予相应的干预措施,其中,模型组、甘麦大枣汤组和香芍颗粒组继续以造模方法给予相应的刺激。香芍颗粒组大鼠灌服香芍颗粒药液(浓度为0.1g/m L);甘麦大枣汤组灌服甘麦大枣汤浓缩药液2m L;正常组和模型组灌服等体积的蒸馏水,均1次/d。各组均干预28d。观察体质量变化情况,同时运用旷场实验、攻击行为测试观察大鼠的行为学变化情况。结果:造模28d后,模型组、甘麦大枣汤组、香芍颗粒组较正常组体质量减轻(P0.01);水平运动距离明显延长(P0.05,P0.01);直立次数明显增多(P0.05);攻击次数、攻击时间显著增多(P0.01);攻击潜伏期时间明显缩短(P0.01);攻击行为总分增高(P0.05)。干预后,甘麦大枣汤组、香芍颗粒组与模型组比较,各项指标改善的差异性显著(P0.01),而甘麦大枣汤组与香芍颗粒组比较,各项指标改善的差异无统计学意义。结论:甘麦大枣汤通过改善"怒"模型大鼠的行为学特征,对异常"怒"发挥调整作用。
[Abstract]:Objective: to study the effect of Ganmai Dazao decoction on behavioral characteristics of rat model of anger. Methods: forty male Wistar rats were randomly divided into normal group, model group, Ganmai Dazao decoction group and Xiangshao granule group, with 10 rats in each group. In addition to the normal group, the other groups made the model by social isolation and residential invasion. After the model was made on the 28th day, each group began to give corresponding intervention measures, among which, the model group, the model group, the model group, the model group, the model group, the model group, the model group, the model group, Ganmai Dazao decoction group and Xiangshao granule group continued to model the corresponding stimulation. The rats of Xiangshao granule group were given Xiangshao granule solution (concentration of 0.1g/m); Ganmai Dazao decoction group was infused with Ganmai Dazao decoction (2m L); the normal group and model group were given distilled water of the same volume, once a day. All groups were treated for 28 days. The changes of body mass were observed, and the behavioral changes of rats were observed by open field experiment and aggressive behavior test. Results: after 28 days of modeling, the model group, Ganmai Dazao decoction group, Xiangshao granule group reduced the body mass of P0.01C, the distance of horizontal exercise significantly prolonged P0.05 P0.01D, the number of upright increased significantly, the number of attacks increased, The attack time increased significantly (P 0.01), the latency time of attack shortened significantly (P 0.01), and the total score of attack behavior increased (P 0.05). After intervention, compared with model group, Ganmai Dazao decoction group, Xiangshao granule group and model group, the difference of each index was significant (P 0.01), but there was no significant difference between Ganmai Dazao decoction group and Xiangshao granule group. Conclusion: Ganmai Dazao decoction can regulate abnormal "anger" by improving its behavioral characteristics.
【作者单位】：上海中医药大学;上海思博职业技术学院;
【基金】：上海市教委科研创新项目(No.14YZ061) 上海中医药大学教师学术共同体项目(No.2013JXG03)~~
【分类号】：R285.5;R-332

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