治疗性抗体半衰期改造研究进展

发布时间：2018-05-13 14:16

  本文选题：治疗性抗体 + 抗体半衰期　； 参考：《中国生物工程杂志》2017年05期

【摘要】：随着治疗性单克隆抗体在临床治疗方面发挥的作用日益突显,其全球药物市场所占份额和研发投入均在逐年增加。除了抗体新药的开发,抗体药物效力和安全性相关的基因工程改造也越来越受到重视。在这些基因工程改造中,抗体半衰期改造已成为近年来研究的热点之一。对几种抗体半衰期改造技术进行了介绍,并简要描述了半衰期改造后抗体的临床研究现状。
[Abstract]:With the increasing role of therapeutic monoclonal antibodies in clinical treatment, its global drug market share and R & D investment are increasing year by year. In addition to the development of new antibody drugs, more and more attention has been paid to the genetic engineering related to the efficacy and safety of antibody drugs. In these genetic engineering modifications, antibody half-life modification has become one of the hotspots in recent years. In this paper, several antibody half-life modification techniques are introduced, and the clinical research status of antibody after half-life modification is briefly described.
【作者单位】： 厦门大学国家传染病诊断试剂与疫苗工程技术研究中心生命科学学院;厦门大学公共卫生学院;
【基金】：国家自然科学基金资助项目(81401668,2017J01066,31600748)
【分类号】：R392
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本文编号：1883528