啮齿类动物模型在食品致敏性评价中作用的研究进展

发布时间：2018-05-22 13:27

本文选题：食物过敏 + 动物模型　；参考：《现代预防医学》2017年09期

【摘要】：食品安全问题受到世界各国的关注,随着新食物产品的不断开发研究,关于是否会增加人体致敏风险等问题成为众专家学者竞相争论的焦点,啮齿类动物模型以其特有的优势在食物致敏性评价中占有重要位置,本文例举了BN大鼠、Balb/c小鼠、C3H/HeJ小鼠此三类最具代表性的啮齿类动物模型,并对致敏过程中常见致敏原及其影响因素、致敏途径和体内检测指标作一综述,为食品致敏性评价提供参考。
[Abstract]:The problem of food safety has attracted the attention of all countries in the world. With the continuous development and research of new food products, the issue of whether it will increase the risk of human sensitization has become the focus of debate among the experts and scholars. The rodent model occupies an important position in the evaluation of food sensitivities with its unique advantages. This article exemplifies the BN rat, Balb/c Mice and C3H/HeJ mice are the three most representative rodent models. The common sensitivities and their influencing factors in the sensitization process, the sensitization pathway and the detection indexes in the body are reviewed to provide a reference for the evaluation of food sensitivities.
【作者单位】：济南大学山东省医学科学院医学与生命科学学院;山东省医学科学院山东省职业卫生与职业病防治研究院;
【基金】：山东省医药卫生科技发展计划项目(2014WS0332)
【分类号】：R155;R-332

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