白藜芦醇在复杂性区域疼痛综合征1型鼠模型中的疗效

发布时间：2018-05-27 02:07

本文选题：复杂性区域疼痛综合征型 + 白藜芦醇　；参考：《实用中西医结合临床》2016年10期

【摘要】：目的:观察白藜芦醇(Resveratrol,Res)对复杂性区域疼痛综合征1型大鼠骨折模型的的抗炎镇痛作用,并探索适合的白藜芦醇治疗剂量。方法:34只SD大鼠分为正常对照组(n=5)、假手术组(n=5)、白藜芦醇治疗1组(n=8)、白藜芦醇治疗2组(n=8)、模型对照组(n=8)。白藜芦醇治疗1、2组分别给予白藜芦醇20 mg/(kg·d)、40 mg/(kg·d)治疗;正常对照组、假手术组及模型对照组予以5%DMSO溶液;连续腹腔注射14 d。在治疗前、第7天、第14天分别测定大鼠疼痛行为,血MIF、TNF-α的表达。结果:在治疗第7天及第14天后,Res治疗1、2组疼痛阈值较治疗前均有明显改善、MIF、TNF-α表达明显下调(P0.05),且显著低于模型对照组(P0.05),其中Res治疗2组比Res治疗1组下降更为显著(P0.05),在治疗第7天TNF-α已降至正常水平,治疗第14天MIF也降至正常水平。结论:白藜芦醇可有效抑制MIF及TNF-α表达,改善CRPS1型鼠模型的疼痛行为,且对MIF抑制作用呈剂量依赖性。
[Abstract]:Aim: to observe the anti-inflammatory and analgesic effects of resveratrol resveratrolone on fracture model of rats with complex regional pain syndrome (type 1) and to explore the appropriate dosage of resveratrol. Methods Thirty-four Sprague-Dawley rats were divided into normal control group (n = 34), sham operation group (n = 5), resveratrol group (n = 8), resveratrol group (n = 2) and model control group (n = 8). Resveratrol group was treated with resveratrol for 20 mg/(kg / d (40 mg/(kg / d), normal control group, sham operation group and model control group were treated with 5%DMSO solution and intraperitoneally injected continuously for 14 days. The pain behavior and the expression of MIF TNF- 伪 were measured before treatment, 7 days and 14 days. Results: on the 7th and 14th day after Res treatment, pain threshold was significantly improved in both groups compared with that before treatment, and the expression of TNF- 伪 was significantly lower than that in the model control group (P 0.05). The decrease of pain threshold in group 2 of Res was more significant than that in group 1 of Res. By the 7th day of treatment, TNF- 伪 had dropped to normal level. On the 14th day of treatment, MIF also decreased to normal level. Conclusion: resveratrol can effectively inhibit the expression of MIF and TNF- 伪, and improve the pain behavior of CRPS1 rat model. The inhibitory effect of resveratrol on MIF is dose-dependent.
【作者单位】：南昌大学医学院;井冈山大学附属医院;南昌大学第一附属医院;
【基金】：江西省科技计划项目(编号:20132BBG70057)
【分类号】：R285.5;R-332

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