六味地黄丸对自发性2型糖尿病模型小鼠肝、肾和胰腺组织学变化的影响

发布时间：2018-05-30 22:06

本文选题：型糖尿病 + 六味地黄丸　；参考：《中国老年学杂志》2017年18期

【摘要】：目的探讨不同剂量六味地黄丸对自发性2型糖尿病(T2DM)模型小鼠肝脏、肾脏和胰腺组织学变化的影响。方法将6~8周龄自发性T2DM模型小鼠(KK-Ay小鼠)随机分为无药对照组、低剂量组和高剂量组,C57BL/6J小鼠作为遗传对照组。各组小鼠分别给予蒸馏水或六味地黄丸灌胃15 w。给药15 w后,HE染色观察小鼠肝脏、肾脏和胰腺组织学变化。结果给药组小鼠肝脏、肾脏和胰腺组织病变明显减轻。低剂量组对小鼠肝脏的保护效果优于高剂量组;高剂量组对肾脏病变的治疗效果好于低剂量组;低剂量组对胰岛内胰岛细胞具有明显的保护作用。结论六味地黄丸对自发性T2DM所致的实验小鼠肝脏、肾脏和胰腺组织病理性改变具有明显的改善作用,且与给药剂量相关。
[Abstract]:Objective to investigate the effects of Liuwei Dihuang pills (LWDW) on the histological changes of liver, kidney and pancreas in mice with spontaneous type 2 diabetes mellitus (T2DM). Methods the 6-week-old spontaneous T2DM model mice (KK-Ay mice) were randomly divided into non-drug control group, low dose group and high dose group C57BL / 6J mice as genetic control group. Mice in each group were given distilled water or Liuwei Dihuang pill for 15 weeks. The histological changes of liver, kidney and pancreas in mice were observed by HE staining 15 weeks after administration. Results the pathological changes of liver, kidney and pancreas in the administration group were obviously alleviated. The protective effect of low dose group on mouse liver was better than that of high dose group; the therapeutic effect of high dose group on renal lesion was better than that of low dose group; low dose group had obvious protective effect on islet cells in islet. Conclusion Liuwei Dihuang pill can improve the pathological changes of liver, kidney and pancreas in mice induced by spontaneous T2DM, and it is related to dosage.
【作者单位】：内蒙古医科大学自治区分子生物学重点实验室;内蒙古医科大学护理学院;
【基金】：内蒙古自治区自然科学基金(2012MS1126) 内蒙古医科大学英才培育项目资助(2015年)
【分类号】：R285.5;R-332

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