SOCS家族蛋白在病毒感染中发挥的作用

发布时间：2018-06-03 01:17

本文选题：SOCS蛋白 + 病毒　；参考：《病毒学报》2017年02期

【摘要】：SOCS(Suppressor of cytokine signaling),是一种细胞因子信号通路抑制蛋白,目前认为该蛋白家族可以调节LIF(Leukemia inhibitory factor)、G-CSF(Granulocyte colony-stimulating factor)、IL-6(Interleukin-6)、IL-10(Interleukin-10)、IFN-λ(interferon-λ)等30多种细胞因子,而这些因子是机体抵抗入侵的外来病原体的主要免疫防御反应。病毒在感染宿主的过程中通过劫持宿主中的SOCS蛋白,从而对细胞中的JAK/STAT、NF-κB等与抗病毒因子调控相关的信号通路以及对T细胞的分化的调控调节病毒感染。近年来,大量的文献证实SOCS蛋白的变化与病毒感染的程度以及愈后的器官损伤具有紧密的联系,使得SOCS蛋白作为抗病毒靶点的研究尤为重要。本文主要讨论SOCS蛋白通过调控JAK-STAT、NF-κB等信号通路,在病毒感染过程中发挥的作用和作用机制。
[Abstract]:SOCS(Suppressor of cytokine signaling is a cytokine signal pathway inhibitor. It is believed that this protein family can modulate more than 30 cytokines such as IL-10, Interleukin-10, IFN- 位 and IFN- 位, which are the main immune defense responses of the body against invading foreign pathogens. In the course of infection, virus hijacks the SOCS protein in the host, thus regulating the signal pathways related to the regulation of antiviral factors, such as JAK / STATNF- 魏 B, and regulating the differentiation of T cells. In recent years, a large number of literatures have confirmed that the changes of SOCS protein are closely related to the degree of virus infection and organ damage after healing, which makes the study of SOCS protein as an antiviral target particularly important. This paper mainly discusses the role and mechanism of SOCS protein in viral infection by regulating JAK-STAT- NF- 魏 B signaling pathway.
【作者单位】：吉林大学第一医院艾滋病与病毒研究所;
【基金】：国家自然科学基金(项目号:31270202),题目:T细胞调节因子在HIV-1Vif形成的E3泛素复合物中作用机制吉林省自然科学基金(项目号:20160101044JC),题目:肠道病毒5'UTR毒力位点确定及分子作用机制的研究吉林省卫生计生委卫生技术创新项目(项目号:2016J065),题目:信号通路在肠道病毒感染中的作用
【分类号】：R373

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